| Name | LRP6 |
| ID | O75581 |
| Role | substrate |
| Enzymatic Domains |
EGF-like 1 282-324
EGF-like 2 588-628
EGF-like 3 889-930
EGF-like 4 1203-1244
LDL-receptor class A 1 1248-1286 PROSITE-ProRule
LDL-receptor class A 2 1287-1323 PROSITE-ProRule
LDL-receptor class A 3 1325-1361 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK2 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 35277657 | SIGNOR-275399 |
| GSK3A | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 35487243 | SIGNOR-275398 |
| CSNK1D | LRP6 | Thr1479 | SSSSTKGtYFPAILN | phosphorylation up-regulates activity | 35487243 | SIGNOR-275402 |
| MAPK3 | LRP6 | – | phosphorylation up-regulates | 20974802 | SIGNOR-169004 | |
| Gbeta | LRP6 | – | phosphorylation up-regulates | 20974802 | SIGNOR-270024 | |
| GSK3B/Axin/APC | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 16341017 | SIGNOR-228014 |
| GSK3B | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 16341017 | SIGNOR-143041 |
| CSNK1E | LRP6 | Ser1430 | LGYVPHPsSLSGSLP | phosphorylation up-regulates | 16513652 | SIGNOR-145053 |
| CyclinY/CDK14 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 24794231 | SIGNOR-273015 |
| CDK14 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates | 20059949 | SIGNOR-162924 |
| PRKACA | LRP6 | – | phosphorylation up-regulates activity | 18981475 | SIGNOR-181979 | |
| CSNK1G3 | LRP6 | Thr1479 | SSSSTKGtYFPAILN | phosphorylation up-regulates activity | 35487243 | SIGNOR-275400 |
| ERK1/2 | LRP6 | – | phosphorylation up-regulates | 20974802 | SIGNOR-244662 | |
| CSNK1E | LRP6 | Ser1420 | YVVHGPAsVPLGYVP | phosphorylation up-regulates | 16513652 | SIGNOR-145049 |
| CSNK1D | LRP6 | Thr1493 | NPPPSPAtERSHYTM | phosphorylation up-regulates activity | 35487243 | SIGNOR-275403 |
| SRC | LRP6 | – | phosphorylation down-regulates activity | 25391905 | SIGNOR-279289 | |
| GRK6 | LRP6 | – | phosphorylation up-regulates activity | 19801552 | SIGNOR-279412 | |
| MAPK8 | LRP6 | – | phosphorylation up-regulates | 20974802 | SIGNOR-169007 | |
| SIK2 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 35277657 | SIGNOR-275404 |
| CSNK1A1L | LRP6 | – | phosphorylation up-regulates | 19293931 | SIGNOR-184699 | |
| CSNK1A1L | LRP6 | – | phosphorylation up-regulates | 21606194 | SIGNOR-173853 | |
| CSNK1A1 | LRP6 | – | phosphorylation up-regulates | 16341017 | SIGNOR-143037 | |
| MAPK1 | LRP6 | – | phosphorylation up-regulates | 20974802 | SIGNOR-169001 | |
| GRK5 | LRP6 | – | phosphorylation up-regulates | 2787365 | SIGNOR-23330 | |
| CSNK1A1 | LRP6 | Thr1493 | NPPPSPAtERSHYTM | phosphorylation up-regulates | 16341017 | SIGNOR-143034 |
| CSNK1G1 | LRP6 | Thr1479 | SSSSTKGtYFPAILN | phosphorylation up-regulates | 16341016 | SIGNOR-143029 |
| PKA | LRP6 | Thr1548 | YAPSRRMtSVATAKG | phosphorylation up-regulates activity | 21406690 | SIGNOR-275416 |
| CSNK1G3 | LRP6 | Thr1493 | NPPPSPAtERSHYTM | phosphorylation up-regulates activity | 35487243 | SIGNOR-275401 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK2 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 35277657 | SIGNOR-275399 |
| GSK3A | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 35487243 | SIGNOR-275398 |
| CSNK1D | phosphorylation up-regulates → | LRP6 PThr1479 | phosphorylation up-regulates → | LRP6 | 35487243 | SIGNOR-275402 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 16341017 | SIGNOR-228014 |
| GSK3B | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 16341017 | SIGNOR-143041 |
| CSNK1E | phosphorylation up-regulates → | LRP6 PSer1430 | phosphorylation up-regulates → | LRP6 | 16513652 | SIGNOR-145053 |
| CyclinY/CDK14 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 24794231 | SIGNOR-273015 |
| CDK14 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 20059949 | SIGNOR-162924 |
| CSNK1G3 | phosphorylation up-regulates → | LRP6 PThr1479 | phosphorylation up-regulates → | LRP6 | 35487243 | SIGNOR-275400 |
| CSNK1E | phosphorylation up-regulates → | LRP6 PSer1420 | phosphorylation up-regulates → | LRP6 | 16513652 | SIGNOR-145049 |
| CSNK1D | phosphorylation up-regulates → | LRP6 PThr1493 | phosphorylation up-regulates → | LRP6 | 35487243 | SIGNOR-275403 |
| SIK2 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 35277657 | SIGNOR-275404 |
| CSNK1A1 | phosphorylation up-regulates → | LRP6 PThr1493 | phosphorylation up-regulates → | LRP6 | 16341017 | SIGNOR-143034 |
| CSNK1G1 | phosphorylation up-regulates → | LRP6 PThr1479 | phosphorylation up-regulates → | LRP6 | 16341016 | SIGNOR-143029 |
| PKA | phosphorylation up-regulates → | LRP6 PThr1548 | phosphorylation up-regulates → | LRP6 | 21406690 | SIGNOR-275416 |
| CSNK1G3 | phosphorylation up-regulates → | LRP6 PThr1493 | phosphorylation up-regulates → | LRP6 | 35487243 | SIGNOR-275401 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SIK2 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275399 |
| GSK3A | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275398 |
| CSNK1D | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275402 |
| MAPK3 | phosphorylation → up-regulates | LRP6 | SIGNOR-169004 |
| Gbeta | phosphorylation → up-regulates | LRP6 | SIGNOR-270024 |
| GSK3B/Axin/APC | phosphorylation → up-regulates activity | LRP6 | SIGNOR-228014 |
| GSK3B | phosphorylation → up-regulates activity | LRP6 | SIGNOR-143041 |
| CSNK1E | phosphorylation → up-regulates | LRP6 | SIGNOR-145053 |
| CyclinY/CDK14 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-273015 |
| CDK14 | phosphorylation → up-regulates | LRP6 | SIGNOR-162924 |
| PRKACA | phosphorylation → up-regulates activity | LRP6 | SIGNOR-181979 |
| CSNK1G3 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275400 |
| ERK1/2 | phosphorylation → up-regulates | LRP6 | SIGNOR-244662 |
| CSNK1E | phosphorylation → up-regulates | LRP6 | SIGNOR-145049 |
| CSNK1D | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275403 |
| SRC | phosphorylation → down-regulates activity | LRP6 | SIGNOR-279289 |
| GRK6 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-279412 |
| MAPK8 | phosphorylation → up-regulates | LRP6 | SIGNOR-169007 |
| SIK2 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275404 |
| CSNK1A1L | phosphorylation → up-regulates | LRP6 | SIGNOR-184699 |
| CSNK1A1L | phosphorylation → up-regulates | LRP6 | SIGNOR-173853 |
| CSNK1A1 | phosphorylation → up-regulates | LRP6 | SIGNOR-143037 |
| MAPK1 | phosphorylation → up-regulates | LRP6 | SIGNOR-169001 |
| GRK5 | phosphorylation → up-regulates | LRP6 | SIGNOR-23330 |
| CSNK1A1 | phosphorylation → up-regulates | LRP6 | SIGNOR-143034 |
| CSNK1G1 | phosphorylation → up-regulates | LRP6 | SIGNOR-143029 |
| PKA | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275416 |
| CSNK1G3 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275401 |