Summary

Name LRP6
Full Name Low-density lipoprotein receptor-related protein 6
Synonyms LRP-6
Primary ID O75581
Links - -
Type protein
Relations 81
Pathways WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.263
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.631
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.732
Publications: 1 Organism: Mus Musculus
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.793
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.343
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.289
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.543
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.55
Publications: 2 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.2
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.255
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation LRP6 0.2
Publications: 1 Organism: Rattus Norvegicus
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png LRP6 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding LRP6 0.905
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.384
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP6 0.615
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.475
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png ubiquitination LRP6 0.655
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.314
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation LRP6 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.754
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png LRP6 0.273
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.648
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.789
Publications: 3 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP6 0.364
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.757
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png binding GSK3B/Axin/APC 0.732
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png LRP6 0.64
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png LRP6 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.827
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP6 0.359
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination LRP6 0.655
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.541
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding LPR5/6 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.617
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization AXIN1 0.835
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.666
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.625
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.737
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.689
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.672
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.706
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding LRP6 0.647
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP6 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.648
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.302
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding LRP6 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP6 0.647
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.638
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:WNT/FLT3
+ up-regulates activity img/direct-activation.png binding LRP6 0.609
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png LRP6 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding DVL1 0.706
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png binding LRP6 0.638
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png LRP6 0.334
Publications: 1
+ up-regulates img/direct-activation.png binding LRP6 0.675
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LRP6 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation LRP6 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation LRP6 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation LRP6 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation LRP6 0.4
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding LRP6 0.497
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png relocalization GSK3B/Axin/APC 0.732
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding LRP6 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png GSK3B 0.793
Publications: 1
Pathways:WNT/FLT3
+ up-regulates activity img/direct-activation.png binding LRP6 0.571
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.546
Publications: 1 Organism: Homo Sapiens