| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK2 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 35277657 | SIGNOR-275404 |
| SIK2 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 35277657 | SIGNOR-275399 |
| GSK3A | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 35487243 | SIGNOR-275398 |
| GSK3B | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 16341017 | SIGNOR-143041 |
| CyclinY/CDK14 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 24794231 | SIGNOR-273015 |
| CDK14 | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates | 20059949 | SIGNOR-162924 |
| GSK3B/Axin/APC | LRP6 | Ser1490 | AILNPPPsPATERSH | phosphorylation up-regulates activity | 16341017 | SIGNOR-228014 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SIK2 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 35277657 | SIGNOR-275404 |
| SIK2 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 35277657 | SIGNOR-275399 |
| GSK3A | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 35487243 | SIGNOR-275398 |
| GSK3B | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 16341017 | SIGNOR-143041 |
| CyclinY/CDK14 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 24794231 | SIGNOR-273015 |
| CDK14 | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 20059949 | SIGNOR-162924 |
| GSK3B/Axin/APC | phosphorylation up-regulates → | LRP6 PSer1490 | phosphorylation up-regulates → | LRP6 | 16341017 | SIGNOR-228014 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SIK2 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275404 |
| SIK2 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275399 |
| GSK3A | phosphorylation → up-regulates activity | LRP6 | SIGNOR-275398 |
| GSK3B | phosphorylation → up-regulates activity | LRP6 | SIGNOR-143041 |
| CyclinY/CDK14 | phosphorylation → up-regulates activity | LRP6 | SIGNOR-273015 |
| CDK14 | phosphorylation → up-regulates | LRP6 | SIGNOR-162924 |
| GSK3B/Axin/APC | phosphorylation → up-regulates activity | LRP6 | SIGNOR-228014 |
