| Name | RPS6KA5 |
| ID | O75582 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 1 49-318 PROSITE-ProRule
AGC-kinase C-terminal 319-387 PROSITE-ProRule
Protein kinase 2 426-687 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA5 | RPS6KA5 | Ser750 | RRKMKKTsTSTETRS | phosphorylation unknown | 15568999 | SIGNOR-131399 |
| RPS6KA5 | RPS6KA5 | Ser752 | KMKKTSTsTETRSSS | phosphorylation unknown | 15568999 | SIGNOR-131403 |
| RPS6KA5 | RPS6KA5 | Ser758 | TSTETRSsSSESSHS | phosphorylation unknown | 15568999 | SIGNOR-131407 |
| RPS6KA5 | RPS6KA5 | Ser212 | DETERAYsFCGTIEY | phosphorylation up-regulates activity | 15568999 | SIGNOR-131387 |
| RPS6KA5 | RPS6KA5 | Ser376 | EKLFQGYsFVAPSIL | phosphorylation up-regulates activity | 15568999 | SIGNOR-131391 |
| RPS6KA5 | RPS6KA5 | Ser381 | GYSFVAPsILFKRNA | phosphorylation up-regulates activity | 15568999 | SIGNOR-131395 |
| RPS6KA5 | HMGN1 | Ser7 | sSAEGAAK | phosphorylation down-regulates activity | 12213813 | SIGNOR-262988 |
| RPS6KA5 | TH | Ser40 | GQGAPGPsLTGSPWP | phosphorylation up-regulates | 12421349 | SIGNOR-95491 |
| RPS6KA5 | H2AC11 | Ser2 | sGRGKQGG | phosphorylation up-regulates | 15010469 | SIGNOR-123383 |
| RPS6KA5 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 9687510 | SIGNOR-59458 |
| RPS6KA5 | ATF1 | Ser63 | GILARRPsYRKILKD | phosphorylation up-regulates activity | 11909979 | SIGNOR-249144 |
| RPS6KA5 | ATF1 | Ser63 | GILARRPsYRKILKD | phosphorylation up-regulates activity | 12414794 | SIGNOR-95318 |
| RPS6KA5 | ELK1 | Ser383 | IHFWSTLsPIAPRSP | phosphorylation up-regulates | 11145955 | SIGNOR-85514 |
| RPS6KA5 | NR4A1 | Ser351 | GRRGRLPsKPKQPPD | phosphorylation unknown | 16223362 | SIGNOR-249296 |
| RPS6KA5 | CTNNB1 | Ser552 | QDTQRRTsMGGTQQQ | phosphorylation up-regulates activity | 27196759 | SIGNOR-278247 |
| RPS6KA5 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates | 12763138 | SIGNOR-101251 |
| RPS6KA5 | STAT3 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166664 | |
| RPS6KA5 | PLA2G4A | Ser727 | RQNPSRCsVSLSNVE | phosphorylation up-regulates activity | 10978317 | SIGNOR-249051 |
| RPS6KA5 | ETV1 | Ser216 | PMYQRQMsEPNIPFP | phosphorylation up-regulates activity | 12213813 | SIGNOR-262987 |
| RPS6KA5 | ATXN1 | – | phosphorylation up-regulates quantity by stabilization | 23719381 | SIGNOR-279109 | |
| RPS6KA5 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-70444 |
| RPS6KA5 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-119237 |
| RPS6KA5 | H3C1 | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-138483 |
| RPS6KA5 | H3C1 | Ser29 | ATKAARKsAPATGGV | phosphorylation down-regulates activity | 20129940 | SIGNOR-163712 |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 10464286 | SIGNOR-70440 |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 14625384 | SIGNOR-119233 |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation down-regulates activity | 15994958 | SIGNOR-138479 |
| RPS6KA5 | H3-3A | Ser29 | ATKAARKsAPSTGGV | phosphorylation down-regulates activity | 18508628 | SIGNOR-178708 |
| RPS6KA5 | H3-3A | Ser11 | TKQTARKsTGGKAPR | phosphorylation up-regulates activity | 18508628 | SIGNOR-178704 |
| RPS6KA5 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 12628924 | SIGNOR-99210 |
| RPS6KA5 | EIF4EBP1 | Thr45 | PGGTLFStTPGGTRI | phosphorylation down-regulates activity | 11777913 | SIGNOR-249131 |
| RPS6KA5 | EIF4EBP1 | Ser65 | FLMECRNsPVTKTPP | phosphorylation down-regulates activity | 12213813 | SIGNOR-262993 |
| RPS6KA5 | EIF4EBP1 | Thr37 | PPGDYSTtPGGTLFS | phosphorylation down-regulates activity | 12213813 | SIGNOR-262991 |
| RPS6KA5 | EIF4EBP1 | Thr46 | GGTLFSTtPGGTRII | phosphorylation down-regulates activity | 12213813 | SIGNOR-262992 |
| RPS6KA5 | EIF4EBP1 | Thr70 | RNSPVTKtPPRDLPT | phosphorylation down-regulates activity | 12213813 | SIGNOR-262994 |
| RPS6KA5 | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 12773393 | SIGNOR-249213 |
| RPS6KA5 | H3-4 | Ser29 | ATKVARKsAPATGGV | phosphorylation unknown | 12773393 | SIGNOR-249214 |
| RPS6KA5 | H2AW | Ser2 | sGRGKQGG | phosphorylation up-regulates activity | 15010469 | SIGNOR-262942 |
| RPS6KA5 | BAD | Ser118 | GRELRRMsDEFVDSF | phosphorylation down-regulates activity | 12213813 | SIGNOR-262990 |
| RPS6KA5 | NfKb-p65/p50 | – | phosphorylation up-regulates | 12628924 | SIGNOR-217424 | |
| RPS6KA5 | Histone H3 | – | phosphorylation down-regulates activity | 10464286 | SIGNOR-265348 | |
| RPS6KA5 | Histone H2A | – | phosphorylation down-regulates | 15010469 | SIGNOR-265314 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer750 | phosphorylation down-regulates ⊣ | RPS6KA5 | 15568999 | SIGNOR-131399 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer752 | phosphorylation down-regulates ⊣ | RPS6KA5 | 15568999 | SIGNOR-131403 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer758 | phosphorylation down-regulates ⊣ | RPS6KA5 | 15568999 | SIGNOR-131407 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer212 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131387 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer376 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131391 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer381 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131395 |
| RPS6KA5 | phosphorylation up-regulates → | HMGN1 PSer7 | phosphorylation down-regulates ⊣ | HMGN1 | 12213813 | SIGNOR-262988 |
| RPS6KA5 | phosphorylation up-regulates → | TH PSer40 | phosphorylation up-regulates → | TH | 12421349 | SIGNOR-95491 |
| RPS6KA5 | phosphorylation up-regulates → | H2AC11 PSer2 | phosphorylation up-regulates → | H2AC11 | 15010469 | SIGNOR-123383 |
| RPS6KA5 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 9687510 | SIGNOR-59458 |
| RPS6KA5 | phosphorylation up-regulates → | ATF1 PSer63 | phosphorylation up-regulates → | ATF1 | 11909979 | SIGNOR-249144 |
| RPS6KA5 | phosphorylation up-regulates → | ATF1 PSer63 | phosphorylation up-regulates → | ATF1 | 12414794 | SIGNOR-95318 |
| RPS6KA5 | phosphorylation up-regulates → | ELK1 PSer383 | phosphorylation up-regulates → | ELK1 | 11145955 | SIGNOR-85514 |
| RPS6KA5 | phosphorylation up-regulates → | NR4A1 PSer351 | phosphorylation down-regulates ⊣ | NR4A1 | 16223362 | SIGNOR-249296 |
| RPS6KA5 | phosphorylation up-regulates → | CTNNB1 PSer552 | phosphorylation up-regulates → | CTNNB1 | 27196759 | SIGNOR-278247 |
| RPS6KA5 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 12763138 | SIGNOR-101251 |
| RPS6KA5 | phosphorylation up-regulates → | PLA2G4A PSer727 | phosphorylation up-regulates → | PLA2G4A | 10978317 | SIGNOR-249051 |
| RPS6KA5 | phosphorylation up-regulates → | ETV1 PSer216 | phosphorylation up-regulates → | ETV1 | 12213813 | SIGNOR-262987 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 10464286 | SIGNOR-70444 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 14625384 | SIGNOR-119237 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer11 | phosphorylation down-regulates ⊣ | H3C1 | 15994958 | SIGNOR-138483 |
| RPS6KA5 | phosphorylation up-regulates → | H3C1 PSer29 | phosphorylation down-regulates ⊣ | H3C1 | 20129940 | SIGNOR-163712 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 10464286 | SIGNOR-70440 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 14625384 | SIGNOR-119233 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation down-regulates ⊣ | H3-3A | 15994958 | SIGNOR-138479 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer29 | phosphorylation down-regulates ⊣ | H3-3A | 18508628 | SIGNOR-178708 |
| RPS6KA5 | phosphorylation up-regulates → | H3-3A PSer11 | phosphorylation up-regulates → | H3-3A | 18508628 | SIGNOR-178704 |
| RPS6KA5 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 12628924 | SIGNOR-99210 |
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PThr45 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 11777913 | SIGNOR-249131 |
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PSer65 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12213813 | SIGNOR-262993 |
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PThr37 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12213813 | SIGNOR-262991 |
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PThr46 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12213813 | SIGNOR-262992 |
| RPS6KA5 | phosphorylation up-regulates → | EIF4EBP1 PThr70 | phosphorylation down-regulates ⊣ | EIF4EBP1 | 12213813 | SIGNOR-262994 |
| RPS6KA5 | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 12773393 | SIGNOR-249213 |
| RPS6KA5 | phosphorylation up-regulates → | H3-4 PSer29 | phosphorylation down-regulates ⊣ | H3-4 | 12773393 | SIGNOR-249214 |
| RPS6KA5 | phosphorylation up-regulates → | H2AW PSer2 | phosphorylation up-regulates → | H2AW | 15010469 | SIGNOR-262942 |
| RPS6KA5 | phosphorylation up-regulates → | BAD PSer118 | phosphorylation down-regulates ⊣ | BAD | 12213813 | SIGNOR-262990 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA5 | phosphorylation → unknown | RPS6KA5 | SIGNOR-131399 |
| RPS6KA5 | phosphorylation → unknown | RPS6KA5 | SIGNOR-131403 |
| RPS6KA5 | phosphorylation → unknown | RPS6KA5 | SIGNOR-131407 |
| RPS6KA5 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131387 |
| RPS6KA5 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131391 |
| RPS6KA5 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131395 |
| RPS6KA5 | phosphorylation → down-regulates activity | HMGN1 | SIGNOR-262988 |
| RPS6KA5 | phosphorylation → up-regulates | TH | SIGNOR-95491 |
| RPS6KA5 | phosphorylation → up-regulates | H2AC11 | SIGNOR-123383 |
| RPS6KA5 | phosphorylation → up-regulates | CREB1 | SIGNOR-59458 |
| RPS6KA5 | phosphorylation → up-regulates activity | ATF1 | SIGNOR-249144 |
| RPS6KA5 | phosphorylation → up-regulates activity | ATF1 | SIGNOR-95318 |
| RPS6KA5 | phosphorylation → up-regulates | ELK1 | SIGNOR-85514 |
| RPS6KA5 | phosphorylation → unknown | NR4A1 | SIGNOR-249296 |
| RPS6KA5 | phosphorylation → up-regulates activity | CTNNB1 | SIGNOR-278247 |
| RPS6KA5 | phosphorylation → up-regulates | STAT3 | SIGNOR-101251 |
| RPS6KA5 | phosphorylation → up-regulates | STAT3 | SIGNOR-166664 |
| RPS6KA5 | phosphorylation → up-regulates activity | PLA2G4A | SIGNOR-249051 |
| RPS6KA5 | phosphorylation → up-regulates activity | ETV1 | SIGNOR-262987 |
| RPS6KA5 | phosphorylation → up-regulates quantity by stabilization | ATXN1 | SIGNOR-279109 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-70444 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-119237 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-138483 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3C1 | SIGNOR-163712 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-70440 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-119233 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-138479 |
| RPS6KA5 | phosphorylation → down-regulates activity | H3-3A | SIGNOR-178708 |
| RPS6KA5 | phosphorylation → up-regulates activity | H3-3A | SIGNOR-178704 |
| RPS6KA5 | phosphorylation → up-regulates | RELA | SIGNOR-99210 |
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-249131 |
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-262993 |
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-262991 |
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-262992 |
| RPS6KA5 | phosphorylation → down-regulates activity | EIF4EBP1 | SIGNOR-262994 |
| RPS6KA5 | phosphorylation → unknown | H3-4 | SIGNOR-249213 |
| RPS6KA5 | phosphorylation → unknown | H3-4 | SIGNOR-249214 |
| RPS6KA5 | phosphorylation → up-regulates activity | H2AW | SIGNOR-262942 |
| RPS6KA5 | phosphorylation → down-regulates activity | BAD | SIGNOR-262990 |
| RPS6KA5 | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217424 |
| RPS6KA5 | phosphorylation → down-regulates activity | Histone H3 | SIGNOR-265348 |
| RPS6KA5 | phosphorylation down-regulates | Histone H2A | SIGNOR-265314 |