Summary

Name RPS6KA5
Full Name Ribosomal protein S6 kinase alpha-5
Synonyms S6K-alpha-5, 90 kDa ribosomal protein S6 kinase 5, Nuclear mitogen- and stress-activated protein kinase 1, RSK-like protein kinase, RSKL | MSK1
Primary ID O75582
Links - -
Type protein
Relations 49
Pathways P38 Signaling, Malignant Melanoma, Adipogenesis
Function Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation HIST1H3A 0.24
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation H3F3A 0.24
Publications: 5 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HIST3H3 0.14
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CREB1 0.53
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma, P38 Signaling
+ down-regulates img/direct_inhibition.png phosphorylation HIST1H2AG 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.34
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma, P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation RELA 0.46
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation NR4A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.46
Publications: 5 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.3
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.34
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.46
Publications: 4 Organism: Homo Sapiens,
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation RPS6KA5 0.4
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.22
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.32
Publications: 1
+ up-regulates activity img/direct-activation.png phosphorylation RPS6KA5 0.34
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma
+ up-regulates img/direct-activation.png phosphorylation ELK1 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation TH 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation ATF1 0.48
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation STAT3 0.4
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLA2G4A 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RPS6KA5 0.34
Publications: 3 Organism: Homo Sapiens
Pathways:Adipogenesis, Malignant Melanoma, P38 Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation NfKb-p65/p50 0.14
Publications: 1 Organism: Homo Sapiens