| Name | RPS6KA5 |
| ID | O75582 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 1 49-318 PROSITE-ProRule
AGC-kinase C-terminal 319-387 PROSITE-ProRule
Protein kinase 2 426-687 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA5 | RPS6KA5 | Ser752 | KMKKTSTsTETRSSS | phosphorylation unknown | 15568999 | SIGNOR-131403 |
| MAPK11 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 9687510 | SIGNOR-59447 |
| RPS6KA5 | RPS6KA5 | Ser381 | GYSFVAPsILFKRNA | phosphorylation up-regulates activity | 15568999 | SIGNOR-131395 |
| MAPK14 | RPS6KA5 | – | phosphorylation up-regulates activity | 9687510 | SIGNOR-59454 | |
| ERK1/2 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 18267068 | SIGNOR-249573 |
| RPS6KA5 | RPS6KA5 | Ser376 | EKLFQGYsFVAPSIL | phosphorylation up-regulates activity | 15568999 | SIGNOR-131391 |
| MAPK14 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates activity | 15568999 | SIGNOR-130736 |
| MAPK1 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 15568999 | SIGNOR-131311 |
| RPS6KA5 | RPS6KA5 | Ser212 | DETERAYsFCGTIEY | phosphorylation up-regulates activity | 15568999 | SIGNOR-131387 |
| MAPK1 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 11940578 | SIGNOR-116485 |
| MAPK1 | RPS6KA5 | Ser376 | EKLFQGYsFVAPSIL | phosphorylation up-regulates activity | 15568999 | SIGNOR-249445 |
| MAPK1 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 11940578 | SIGNOR-116489 |
| MAPK1 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 18267068 | SIGNOR-160787 |
| RPS6KA5 | RPS6KA5 | Ser758 | TSTETRSsSSESSHS | phosphorylation unknown | 15568999 | SIGNOR-131407 |
| ERK1/2 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 18267068 | SIGNOR-249572 |
| MAPK3 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 15568999 | SIGNOR-131383 |
| MAPK14 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates activity | 15568999 | SIGNOR-131375 |
| MAPK3 | RPS6KA5 | Ser376 | EKLFQGYsFVAPSIL | phosphorylation up-regulates activity | 15568999 | SIGNOR-249479 |
| MAPK3 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 15568999 | SIGNOR-131379 |
| MAPK11 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 9687510 | SIGNOR-59443 |
| ERK1/2 | RPS6KA5 | Ser376 | EKLFQGYsFVAPSIL | phosphorylation up-regulates activity | 15568999 | SIGNOR-249574 |
| MAPK14 | RPS6KA5 | Ser376 | EKLFQGYsFVAPSIL | phosphorylation up-regulates activity | 15568999 | SIGNOR-249199 |
| MAPK1 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 9687510 | SIGNOR-59435 |
| RPS6KA5 | RPS6KA5 | Ser750 | RRKMKKTsTSTETRS | phosphorylation unknown | 15568999 | SIGNOR-131399 |
| MAPK11 | RPS6KA5 | Thr700 | LSSNPLMtPDILGSS | phosphorylation up-regulates | 9687510 | SIGNOR-59451 |
| Gbeta | RPS6KA5 | – | phosphorylation up-regulates | 15568999 | SIGNOR-270076 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer752 | phosphorylation down-regulates ⊣ | RPS6KA5 | 15568999 | SIGNOR-131403 |
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59447 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer381 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131395 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-249573 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer376 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131391 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-130736 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131311 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer212 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131387 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 11940578 | SIGNOR-116485 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PSer376 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-249445 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 11940578 | SIGNOR-116489 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-160787 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer758 | phosphorylation down-regulates ⊣ | RPS6KA5 | 15568999 | SIGNOR-131407 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-249572 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131383 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131375 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA5 PSer376 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-249479 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131379 |
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59443 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PSer376 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-249574 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA5 PSer376 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-249199 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59435 |
| RPS6KA5 | phosphorylation up-regulates → | RPS6KA5 PSer750 | phosphorylation down-regulates ⊣ | RPS6KA5 | 15568999 | SIGNOR-131399 |
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PThr700 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59451 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA5 | phosphorylation → unknown | RPS6KA5 | SIGNOR-131403 |
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59447 |
| RPS6KA5 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131395 |
| MAPK14 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-59454 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-249573 |
| RPS6KA5 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131391 |
| MAPK14 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-130736 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-131311 |
| RPS6KA5 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131387 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-116485 |
| MAPK1 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-249445 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-116489 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-160787 |
| RPS6KA5 | phosphorylation → unknown | RPS6KA5 | SIGNOR-131407 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-249572 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-131383 |
| MAPK14 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131375 |
| MAPK3 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-249479 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-131379 |
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59443 |
| ERK1/2 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-249574 |
| MAPK14 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-249199 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59435 |
| RPS6KA5 | phosphorylation → unknown | RPS6KA5 | SIGNOR-131399 |
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59451 |
| Gbeta | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-270076 |