| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK11 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 9687510 | SIGNOR-59447 |
| ERK1/2 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 18267068 | SIGNOR-249573 |
| MAPK1 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 11940578 | SIGNOR-116489 |
| MAPK1 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 18267068 | SIGNOR-160787 |
| MAPK3 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates | 15568999 | SIGNOR-131383 |
| MAPK14 | RPS6KA5 | Thr581 | PDNQPLKtPCFTLHY | phosphorylation up-regulates activity | 15568999 | SIGNOR-131375 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59447 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-249573 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 11940578 | SIGNOR-116489 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-160787 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131383 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA5 PThr581 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131375 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59447 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-249573 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-116489 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-160787 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-131383 |
| MAPK14 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-131375 |
