| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 9687510 | SIGNOR-59435 |
| MAPK14 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates activity | 15568999 | SIGNOR-130736 |
| MAPK1 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 15568999 | SIGNOR-131311 |
| MAPK1 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 11940578 | SIGNOR-116485 |
| ERK1/2 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 18267068 | SIGNOR-249572 |
| MAPK3 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 15568999 | SIGNOR-131379 |
| MAPK11 | RPS6KA5 | Ser360 | TEMDPTYsPAALPQS | phosphorylation up-regulates | 9687510 | SIGNOR-59443 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59435 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-130736 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131311 |
| MAPK1 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 11940578 | SIGNOR-116485 |
| ERK1/2 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 18267068 | SIGNOR-249572 |
| MAPK3 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 15568999 | SIGNOR-131379 |
| MAPK11 | phosphorylation up-regulates → | RPS6KA5 PSer360 | phosphorylation up-regulates → | RPS6KA5 | 9687510 | SIGNOR-59443 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59435 |
| MAPK14 | phosphorylation → up-regulates activity | RPS6KA5 | SIGNOR-130736 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-131311 |
| MAPK1 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-116485 |
| ERK1/2 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-249572 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-131379 |
| MAPK11 | phosphorylation → up-regulates | RPS6KA5 | SIGNOR-59443 |
