| Name | RPS6KA4 |
| ID | O75676 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 1 33-301 PROSITE-ProRule
AGC-kinase C-terminal 302-371 PROSITE-ProRule
Protein kinase 2 411-674 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA4 | RPS6KA4 | Ser196 | EEKERTFsFCGTIEY | phosphorylation up-regulates | 17429437 | SIGNOR-154324 |
| RPS6KA4 | RPS6KA4 | Ser196 | EEKERTFsFCGTIEY | phosphorylation up-regulates activity | 19933278 | SIGNOR-276269 |
| RPS6KA4 | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 16055710 | SIGNOR-263000 |
| RPS6KA4 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 22187936 | SIGNOR-191678 |
| RPS6KA4 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-37216 |
| RPS6KA4 | HMGN1 | Ser7 | sSAEGAAK | phosphorylation unknown | 12773393 | SIGNOR-249216 |
| RPS6KA4 | CREB1 | Ser119 | EILSRRPsYRKILND | phosphorylation up-regulates | 17668895 | SIGNOR-157158 |
| RPS6KA4 | ATF1 | – | phosphorylation up-regulates | 11909979 | SIGNOR-116252 | |
| RPS6KA4 | ATF1 | – | phosphorylation up-regulates | 20626350 | SIGNOR-166661 | |
| RPS6KA4 | ATF1 | Ser63 | GILARRPsYRKILKD | phosphorylation up-regulates activity | 11909979 | SIGNOR-249145 |
| RPS6KA4 | RELA | Ser276 | SMQLRRPsDRELSEP | phosphorylation up-regulates | 17183360 | SIGNOR-151436 |
| RPS6KA4 | H3-4 | Ser11 | TKQTARKsTGGKAPR | phosphorylation unknown | 12773393 | SIGNOR-249211 |
| RPS6KA4 | H3-4 | Ser29 | ATKVARKsAPATGGV | phosphorylation unknown | 12773393 | SIGNOR-249212 |
| RPS6KA4 | NfKb-p65/p50 | – | phosphorylation up-regulates | 17183360 | SIGNOR-217373 | |
| RPS6KA4 | Histone H3 | – | phosphorylation unknown | 12773393 | SIGNOR-265355 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA4 | phosphorylation up-regulates → | RPS6KA4 PSer196 | phosphorylation up-regulates → | RPS6KA4 | 17429437 | SIGNOR-154324 |
| RPS6KA4 | phosphorylation up-regulates → | RPS6KA4 PSer196 | phosphorylation up-regulates → | RPS6KA4 | 19933278 | SIGNOR-276269 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263000 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 22187936 | SIGNOR-191678 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-37216 |
| RPS6KA4 | phosphorylation up-regulates → | HMGN1 PSer7 | phosphorylation down-regulates ⊣ | HMGN1 | 12773393 | SIGNOR-249216 |
| RPS6KA4 | phosphorylation up-regulates → | CREB1 PSer119 | phosphorylation up-regulates → | CREB1 | 17668895 | SIGNOR-157158 |
| RPS6KA4 | phosphorylation up-regulates → | ATF1 PSer63 | phosphorylation up-regulates → | ATF1 | 11909979 | SIGNOR-249145 |
| RPS6KA4 | phosphorylation up-regulates → | RELA PSer276 | phosphorylation up-regulates → | RELA | 17183360 | SIGNOR-151436 |
| RPS6KA4 | phosphorylation up-regulates → | H3-4 PSer11 | phosphorylation down-regulates ⊣ | H3-4 | 12773393 | SIGNOR-249211 |
| RPS6KA4 | phosphorylation up-regulates → | H3-4 PSer29 | phosphorylation down-regulates ⊣ | H3-4 | 12773393 | SIGNOR-249212 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KA4 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-154324 |
| RPS6KA4 | phosphorylation → up-regulates activity | RPS6KA4 | SIGNOR-276269 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-263000 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-191678 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-37216 |
| RPS6KA4 | phosphorylation → unknown | HMGN1 | SIGNOR-249216 |
| RPS6KA4 | phosphorylation → up-regulates | CREB1 | SIGNOR-157158 |
| RPS6KA4 | phosphorylation → up-regulates | ATF1 | SIGNOR-116252 |
| RPS6KA4 | phosphorylation → up-regulates | ATF1 | SIGNOR-166661 |
| RPS6KA4 | phosphorylation → up-regulates activity | ATF1 | SIGNOR-249145 |
| RPS6KA4 | phosphorylation → up-regulates | RELA | SIGNOR-151436 |
| RPS6KA4 | phosphorylation → unknown | H3-4 | SIGNOR-249211 |
| RPS6KA4 | phosphorylation → unknown | H3-4 | SIGNOR-249212 |
| RPS6KA4 | phosphorylation → up-regulates | NfKb-p65/p50 | SIGNOR-217373 |
| RPS6KA4 | phosphorylation → unknown | Histone H3 | SIGNOR-265355 |