| + |
RPS6KA4 |
phosphorylation
|
H3-4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249211 |
Ser11 |
TKQTARKsTGGKAPR |
Mus musculus |
|
| pmid |
sentence |
| 12773393 |
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249212 |
Ser29 |
ATKVARKsAPATGGV |
Mus musculus |
|
| pmid |
sentence |
| 12773393 |
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28 |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
RPS6KA4 | up-regulates 
phosphorylation
|
CREB1 |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157158 |
Ser119 |
EILSRRPsYRKILND |
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17668895 |
Msk1 and msk2 directly phosphorilate and activete transcription factors such as creb1, atf1 msk was the kinase responsible for phosphorylation of the transcription factor creb in response to tcr stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates activity
phosphorylation
|
RPS6KA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276269 |
Ser196 |
EEKERTFsFCGTIEY |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19933278 |
Here we report that the CK2 protein kinase, which contributes to NF-kappaB activation following UV radiation in a p38-dependent manner, physically interacts with MSK2 but not MSK1 and that CK2 inhibition specifically impairs UV-induced MSK2 kinase activation. A putative site of CK2 phosphorylation was mapped to MSK2 residue Ser(324) and when substituted to alanine (S324A) also compromised MSK2 activity.Serine 324 is required for UV-induced MSK2 activation and for autophosphorylation at MSK2-Ser196. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates
phosphorylation
|
RPS6KA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-154324 |
Ser196 |
EEKERTFsFCGTIEY |
Homo sapiens |
|
| pmid |
sentence |
| 17429437 |
Ser-343 and ser-196 are autophosphorylated by the c-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the n-terminal kinase domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skin |
| + |
MAPK14 | up-regulates
phosphorylation
|
RPS6KA4 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77204 |
Ser196 |
EEKERTFsFCGTIEY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77208 |
Ser343 |
TRLEPVYsPPGSPPP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77212 |
Ser347 |
PVYSPPGsPPPGDPR |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77216 |
Ser360 |
PRIFQGYsFVAPSIL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77220 |
Thr568 |
SPGVPMQtPCFTLQY |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10806207 |
Rskb, a 90-kda ribosomal s6 protein kinase family (rsk) member with two complete catalytic domains connected by a linker, is activated through p38- and erk-mitogen-activated protein kinases. unlike other rsks, the activation loop phosphorylation sites of both catalytic domains of rskb, ser(196) and thr(568), were required for activity. Rskb activation depended on phosphorylation of linker ser(343) and ser(360) and associated with phosphorylation of nonconserved ser(347), but ser(347)-deficient rskb retained partial activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60995 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9792677 |
Rsk-b is a p38alphamapk substrate, and activated by p38alphamapk and, more weakly, by erk1 |
|
| Publications: |
6 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates
phosphorylation
|
RELA |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151436 |
Ser276 |
SMQLRRPsDRELSEP |
Homo sapiens |
|
| pmid |
sentence |
| 17183360 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) msk 1 and 2 can directly phosphorylate and activate transcription factors such as creb, atf1, the nf-kb isoform p65 and stat 1 and 3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | up-regulates activity
phosphorylation
|
RPS6KA4 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276268 |
Ser324 |
PFRPQIRsELDVGNF |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 19933278 |
Here we report that the CK2 protein kinase, which contributes to NF-kappaB activation following UV radiation in a p38-dependent manner, physically interacts with MSK2 but not MSK1 and that CK2 inhibition specifically impairs UV-induced MSK2 kinase activation. A putative site of CK2 phosphorylation was mapped to MSK2 residue Ser(324) and when substituted to alanine (S324A) also compromised MSK2 activity.Serine 324 is required for UV-induced MSK2 activation and for autophosphorylation at MSK2-Ser196. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates activity
phosphorylation
|
FOS |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37216 |
Ser362 |
AAAHRKGsSSNEPSS |
Homo sapiens |
|
| pmid |
sentence |
| 8248197 |
Rsk1/2 phosphorylates the transcription factor c-fos on s362 and increases its activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-191678 |
Ser362 |
AAAHRKGsSSNEPSS |
Homo sapiens |
|
| pmid |
sentence |
| 22187936 |
Rsk1/2 stabilize c-fos and increases its activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263000 |
Ser374 |
PSSDSLSsPTLLAL |
|
|
| pmid |
sentence |
| 16055710 |
Serine 374 and serine 362 are the primary sites targeted by Erk1/2 and the mitogen-activated protein kinase-activated kinases Rsk1/2 (12, 13, 37, 38, 41), respectively. Their phosphorylation leads to protein stabilization (3, 13, 20, 41). Threonine 325 and threonine 331 are secondary targets of Erk1/2; their modification occurs only when serines 362 and 374 are phosphorylated and Erk1/2 activation is sufficiently sustained (37, 38). This enhances the transcriptional activity of c-Fos |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, |
| + |
RPS6KA4 | up-regulates activity
phosphorylation
|
ATF1 |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249145 |
Ser63 |
GILARRPsYRKILKD |
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 11909979 |
Using embryonic fibroblasts derived from these mice we were able to demonstrate an important role for these enzymes in the activation of CREB and the closely related transcription factor ATF1. | Our results clearly demonstrate that MSK1 and MSK2 are the major, if not the only, protein kinases that mediate the phosphorylation of CREB at Ser133 and of ATF1 at Ser63 in fibroblasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RPS6KA4 |
phosphorylation
|
HMGN1 |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249216 |
Ser7 |
sSAEGAAK |
Mus musculus |
Fibroblast |
| pmid |
sentence |
| 12773393 |
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28 and HMG-14 at Ser6 after stimulation of primary embryonic fibroblasts by TPA or anisomycin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RPS6KA4 |
phosphorylation
|
Histone H3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265355 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12773393 |
The results presented here show that MSK2 and, to a lesser extent, MSK1 are the major protein kinases required for the phosphorylation of histone H3 at both Ser10 and Ser28 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
RPS6KA4 | up-regulates
phosphorylation
|
NfKb-p65/p50 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217373 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17183360 |
Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also known as tank-binding kinase-1 tbk1)) and rsk1 (also known as p90 ribosomal protein s6 kinase (p90s6k) msk 1 and 2 can directly phosphorylate and activate transcription factors such as creb, atf1, the nf-kb isoform p65 and stat 1 and 3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD3G | up-regulates 
|
RPS6KA4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157148 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 17668895 |
Tcr stimulation also activates the mitogen- and stress-activated kinases (msk) downstream of erk1/2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | up-regulates
phosphorylation
|
ATF1 |
0.599 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Msk1 and msk2 directly phosphorilate and activate transcription factors such as creb1, atf1. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116252 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11909979 |
Msk1 and msk2 directly phosphorilate and activate transcription factors such as creb1, atf1. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK3 | up-regulates
phosphorylation
|
RPS6KA4 |
0.567 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9792677 |
Rsk-b is a p38alphamapk substrate, and activated by p38alphamapk and, more weakly, by erk1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA4 | down-regulates 
|
TP53 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188334 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19797274 |
Mitogen- and stress-activated kinase 2 (msk2) inhibits the transcription factor p53, and we investigate here the mechanisms underlying this inhibition. In the absence of stress stimuli, msk2 selectively suppressed the expression of a subset of p53 target genes.Msk2 can also control the the transcriptional activity of p53 in a kinase-indipendent mannermsk2 can also control the the transcriptional activity of p53 in a kinase-indipendent manner |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RPS6KA4
- 
- 