| Name | RPS6KA4 |
| ID | O75676 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 1 33-301 PROSITE-ProRule
AGC-kinase C-terminal 302-371 PROSITE-ProRule
Protein kinase 2 411-674 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | RPS6KA4 | – | phosphorylation up-regulates | 9792677 | SIGNOR-60995 | |
| RPS6KA4 | RPS6KA4 | Ser196 | EEKERTFsFCGTIEY | phosphorylation up-regulates | 17429437 | SIGNOR-154324 |
| RPS6KA4 | RPS6KA4 | Ser196 | EEKERTFsFCGTIEY | phosphorylation up-regulates activity | 19933278 | SIGNOR-276269 |
| MAPK14 | RPS6KA4 | Ser360 | PRIFQGYsFVAPSIL | phosphorylation up-regulates | 10806207 | SIGNOR-77216 |
| MAPK3 | RPS6KA4 | – | phosphorylation up-regulates | 9792677 | SIGNOR-60998 | |
| MAPK14 | RPS6KA4 | Thr568 | SPGVPMQtPCFTLQY | phosphorylation up-regulates | 10806207 | SIGNOR-77220 |
| MAPK14 | RPS6KA4 | Ser347 | PVYSPPGsPPPGDPR | phosphorylation up-regulates | 10806207 | SIGNOR-77212 |
| CSNK2A1 | RPS6KA4 | Ser324 | PFRPQIRsELDVGNF | phosphorylation up-regulates activity | 19933278 | SIGNOR-276268 |
| MAPK14 | RPS6KA4 | Ser343 | TRLEPVYsPPGSPPP | phosphorylation up-regulates | 10806207 | SIGNOR-77208 |
| MAPK14 | RPS6KA4 | Ser196 | EEKERTFsFCGTIEY | phosphorylation up-regulates | 10806207 | SIGNOR-77204 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA4 | phosphorylation up-regulates → | RPS6KA4 PSer196 | phosphorylation up-regulates → | RPS6KA4 | 17429437 | SIGNOR-154324 |
| RPS6KA4 | phosphorylation up-regulates → | RPS6KA4 PSer196 | phosphorylation up-regulates → | RPS6KA4 | 19933278 | SIGNOR-276269 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA4 PSer360 | phosphorylation up-regulates → | RPS6KA4 | 10806207 | SIGNOR-77216 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA4 PThr568 | phosphorylation up-regulates → | RPS6KA4 | 10806207 | SIGNOR-77220 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA4 PSer347 | phosphorylation up-regulates → | RPS6KA4 | 10806207 | SIGNOR-77212 |
| CSNK2A1 | phosphorylation up-regulates → | RPS6KA4 PSer324 | phosphorylation up-regulates → | RPS6KA4 | 19933278 | SIGNOR-276268 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA4 PSer343 | phosphorylation up-regulates → | RPS6KA4 | 10806207 | SIGNOR-77208 |
| MAPK14 | phosphorylation up-regulates → | RPS6KA4 PSer196 | phosphorylation up-regulates → | RPS6KA4 | 10806207 | SIGNOR-77204 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-60995 |
| RPS6KA4 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-154324 |
| RPS6KA4 | phosphorylation → up-regulates activity | RPS6KA4 | SIGNOR-276269 |
| MAPK14 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-77216 |
| MAPK3 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-60998 |
| MAPK14 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-77220 |
| MAPK14 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-77212 |
| CSNK2A1 | phosphorylation → up-regulates activity | RPS6KA4 | SIGNOR-276268 |
| MAPK14 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-77208 |
| MAPK14 | phosphorylation → up-regulates | RPS6KA4 | SIGNOR-77204 |