| Name | PPM1B |
| ID | O75688 |
| Role | phosphatase |
| Enzymatic Domains |
PPM-type phosphatase 23-295 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1B | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates | 18930133 | SIGNOR-181663 |
| PPM1B | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates | 18930133 | SIGNOR-181667 |
| PPM1B | IKBKB | Ser177 | AKELDQGsLCTSFVG | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248343 |
| PPM1B | IKBKB | Ser181 | DQGSLCTsFVGTLQY | dephosphorylation down-regulates activity | 18930133 | SIGNOR-248344 |
| PPM1B | MAP3K7 | – | dephosphorylation down-regulates activity | 11104763 | SIGNOR-277154 | |
| PPM1B | CDK2 | – | dephosphorylation down-regulates activity | 20538721 | SIGNOR-277153 | |
| PPM1B | PPARG | – | dephosphorylation up-regulates activity | 23320500 | SIGNOR-277073 | |
| PPM1B | CDK9 | Thr186 | NSQPNRYtNRVVTLW | dephosphorylation unknown | 18829461 | SIGNOR-181396 |
| PPM1B | PAX2 | – | dephosphorylation down-regulates activity | 25631048 | SIGNOR-251712 | |
| PPM1B | DYRK1A | Ser258 | NTNFRGVsLNLTRKF | dephosphorylation down-regulates activity | 33380426 | SIGNOR-277108 |
| PPM1B | MPRIP | – | dephosphorylation down-regulates activity | 25751141 | SIGNOR-277019 | |
| PPM1B | TBK1 | – | dephosphorylation down-regulates activity | 22750291 | SIGNOR-276985 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181663 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-181667 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer177 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248343 |
| PPM1B | dephosphorylation down-regulates ⊣ | IKBKB PSer181 | dephosphorylation up-regulates → | IKBKB | 18930133 | SIGNOR-248344 |
| PPM1B | dephosphorylation down-regulates ⊣ | CDK9 PThr186 | dephosphorylation up-regulates → | CDK9 | 18829461 | SIGNOR-181396 |
| PPM1B | dephosphorylation down-regulates ⊣ | DYRK1A PSer258 | dephosphorylation up-regulates → | DYRK1A | 33380426 | SIGNOR-277108 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPM1B | dephosphorylation down-regulates | IKBKB | SIGNOR-181663 |
| PPM1B | dephosphorylation down-regulates | IKBKB | SIGNOR-181667 |
| PPM1B | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248343 |
| PPM1B | dephosphorylation → down-regulates activity | IKBKB | SIGNOR-248344 |
| PPM1B | dephosphorylation → down-regulates activity | MAP3K7 | SIGNOR-277154 |
| PPM1B | dephosphorylation → down-regulates activity | CDK2 | SIGNOR-277153 |
| PPM1B | dephosphorylation → up-regulates activity | PPARG | SIGNOR-277073 |
| PPM1B | dephosphorylation → unknown | CDK9 | SIGNOR-181396 |
| PPM1B | dephosphorylation → down-regulates activity | PAX2 | SIGNOR-251712 |
| PPM1B | dephosphorylation → down-regulates activity | DYRK1A | SIGNOR-277108 |
| PPM1B | dephosphorylation → down-regulates activity | MPRIP | SIGNOR-277019 |
| PPM1B | dephosphorylation → down-regulates activity | TBK1 | SIGNOR-276985 |