+ |
PPM1B | down-regulates
dephosphorylation
|
IKBKB |
0.413 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-181663 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
pmid |
sentence |
18930133 |
Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, ppm1a and ppm1b, as ikkbeta phosphatases. Overexpression of ppm1a or ppm1b results in dephosphorylation of ikkbeta at ser177 and ser181 and termination of ikkbeta-induced nf-kappab activation |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-181667 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
pmid |
sentence |
18930133 |
Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, ppm1a and ppm1b, as ikkbeta phosphatases. Overexpression of ppm1a or ppm1b results in dephosphorylation of ikkbeta at ser177 and ser181 and termination of ikkbeta-induced nf-kappab activation |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
PPM1B | down-regulates activity
dephosphorylation
|
IKBKB |
0.413 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-248343 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
pmid |
sentence |
18930133 |
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation|Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-248344 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
pmid |
sentence |
18930133 |
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation|Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
PPM1B |
dephosphorylation
|
CDK9 |
0.387 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-181396 |
Thr186 |
NSQPNRYtNRVVTLW |
Homo sapiens |
|
pmid |
sentence |
18829461 |
Taken together, our data indicate that PPM1A and to some extent PPM1B are important negative regulators of P-TEFb function |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPM1B | down-regulates activity
dephosphorylation
|
PAX2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251712 |
|
|
Homo sapiens |
|
pmid |
sentence |
25631048 |
PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
HEK-293 Cell |
Pathways: | Focal segmental glomerulosclerosis |