| + |
PPM1B | down-regulates activity 
dephosphorylation
|
IKBKB |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248343 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation|Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248344 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation|Overexpression of PPM1A or PPM1B results in dephosphorylation of IKKbeta at Ser177 and Ser181 and termination of IKKbeta-induced NF-kappaB activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPM1B | down-regulates
dephosphorylation
|
IKBKB |
0.394 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181663 |
Ser177 |
AKELDQGsLCTSFVG |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, ppm1a and ppm1b, as ikkbeta phosphatases. Overexpression of ppm1a or ppm1b results in dephosphorylation of ikkbeta at ser177 and ser181 and termination of ikkbeta-induced nf-kappab activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-181667 |
Ser181 |
DQGSLCTsFVGTLQY |
Homo sapiens |
|
| pmid |
sentence |
| 18930133 |
Using a functional genomic approach, we have identified two protein serine/threonine phosphatases, ppm1a and ppm1b, as ikkbeta phosphatases. Overexpression of ppm1a or ppm1b results in dephosphorylation of ikkbeta at ser177 and ser181 and termination of ikkbeta-induced nf-kappab activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PKA | down-regulates quantity by destabilization
phosphorylation
|
PPM1B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277825 |
Ser195 |
MIQRVNGsLAVSRAL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23756813 |
Collectively, these data suggest that PKA destabilizes PP2Cβ upon inflammatory stimuli via phosphorylation of Ser-195 in PP2Cβ. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276494 |
Ser195 |
MIQRVNGsLAVSRAL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23756813 |
Here, we show that protein kinase A (PKA) phosphorylates the PP2Cβ, which was inhibited by PKA-specific inhibitor, H89. Mutation analysis of serine residues in PP2Cβ revealed that Ser-195 in PP2Cβ is phosphorylated by PKA. Importantly, PKA inhibition by H89 abrogated the Forskolin-induced destabilization of PP2Cβ against ubiquitin-dependent proteosomal degradation pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPM1B | down-regulates activity
dephosphorylation
|
DYRK1A |
0.235 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277108 |
Ser258 |
NTNFRGVsLNLTRKF |
Homo sapiens |
|
| pmid |
sentence |
| 33380426 |
In conclusion, our study demonstrates that DYRK1A autophosphorylates Ser258, the dephosphorylation target of PPM1B, and PPM1B negatively regulates DYRK1A activity.|We found that PPM1B dephosphorylates DYRK1A at Ser258, contributing to the inhibition of DYRK1A activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1B |
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PPM1B
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