| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | RAD17 | Ser646 | ETWSLPLsQNSASEL | phosphorylation up-regulates activity | 11687627 | SIGNOR-111248 |
| ATM | RAD17 | Ser646 | ETWSLPLsQNSASEL | phosphorylation unknown | 10608806 | SIGNOR-73520 |
| ATM | RAD17 | Ser656 | SASELPAsQPQPFSA | phosphorylation unknown | 10608806 | SIGNOR-73524 |
| ATR | RAD17 | Ser656 | SASELPAsQPQPFSA | phosphorylation up-regulates activity | 11687627 | SIGNOR-111252 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATR | phosphorylation up-regulates → | RAD17 PSer646 | phosphorylation up-regulates → | RAD17 | 11687627 | SIGNOR-111248 |
| ATM | phosphorylation up-regulates → | RAD17 PSer646 | phosphorylation down-regulates ⊣ | RAD17 | 10608806 | SIGNOR-73520 |
| ATM | phosphorylation up-regulates → | RAD17 PSer656 | phosphorylation down-regulates ⊣ | RAD17 | 10608806 | SIGNOR-73524 |
| ATR | phosphorylation up-regulates → | RAD17 PSer656 | phosphorylation up-regulates → | RAD17 | 11687627 | SIGNOR-111252 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATR | phosphorylation → up-regulates activity | RAD17 | SIGNOR-111248 |
| ATM | phosphorylation → unknown | RAD17 | SIGNOR-73520 |
| ATM | phosphorylation → unknown | RAD17 | SIGNOR-73524 |
| ATR | phosphorylation → up-regulates activity | RAD17 | SIGNOR-111252 |
