| Name | PRKD3 |
| ID | O94806 |
| Role | kinase |
| Enzymatic Domains |
PH 416-532 PROSITE-ProRule
Protein kinase 576-832 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD3 | PAK4 | Ser474 | KEVPRRKsLVGTPYW | phosphorylation up-regulates activity | 23841590 | SIGNOR-275931 |
| PRKD3 | HDAC7 | Ser155 | FPLRKTVsEPNLKLR | phosphorylation up-regulates activity | 18692497 | SIGNOR-275932 |
| PRKD3 | HDAC7 | Ser358 | WPLSRTRsEPLPPSA | phosphorylation up-regulates activity | 18692497 | SIGNOR-275934 |
| PRKD3 | SSH1 | Ser978 | SPLKRSHsLAKLGSL | phosphorylation down-regulates activity | 21832093 | SIGNOR-275938 |
| PRKD3 | MFF | Ser155 | GRLKRERsMSENAVR | phosphorylation up-regulates activity | 34010649 | SIGNOR-275945 |
| PRKD3 | MFF | Ser172 | GQLVRNDsLWHRSDS | phosphorylation up-regulates activity | 34010649 | SIGNOR-275940 |
| PRKD3 | MFF | Ser275 | DNVRYGIsNIDTTIE | phosphorylation up-regulates activity | 34010649 | SIGNOR-275946 |
| PRKD3 | HDAC5 | Ser259 | FPLRKTAsEPNLKVR | phosphorylation up-regulates activity | 18692497 | SIGNOR-275926 |
| PRKD3 | HDAC5 | Ser498 | RPLSRTQsSPLPQSP | phosphorylation up-regulates activity | 18692497 | SIGNOR-275928 |
| PRKD3 | GIT1 | Ser46 | RSLGRHIsIVKHLRH | phosphorylation unknown | 22893698 | SIGNOR-191839 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKD3 | phosphorylation up-regulates → | PAK4 PSer474 | phosphorylation up-regulates → | PAK4 | 23841590 | SIGNOR-275931 |
| PRKD3 | phosphorylation up-regulates → | HDAC7 PSer155 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275932 |
| PRKD3 | phosphorylation up-regulates → | HDAC7 PSer358 | phosphorylation up-regulates → | HDAC7 | 18692497 | SIGNOR-275934 |
| PRKD3 | phosphorylation up-regulates → | SSH1 PSer978 | phosphorylation down-regulates ⊣ | SSH1 | 21832093 | SIGNOR-275938 |
| PRKD3 | phosphorylation up-regulates → | MFF PSer155 | phosphorylation up-regulates → | MFF | 34010649 | SIGNOR-275945 |
| PRKD3 | phosphorylation up-regulates → | MFF PSer172 | phosphorylation up-regulates → | MFF | 34010649 | SIGNOR-275940 |
| PRKD3 | phosphorylation up-regulates → | MFF PSer275 | phosphorylation up-regulates → | MFF | 34010649 | SIGNOR-275946 |
| PRKD3 | phosphorylation up-regulates → | HDAC5 PSer259 | phosphorylation up-regulates → | HDAC5 | 18692497 | SIGNOR-275926 |
| PRKD3 | phosphorylation up-regulates → | HDAC5 PSer498 | phosphorylation up-regulates → | HDAC5 | 18692497 | SIGNOR-275928 |
| PRKD3 | phosphorylation up-regulates → | GIT1 PSer46 | phosphorylation down-regulates ⊣ | GIT1 | 22893698 | SIGNOR-191839 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKD3 | phosphorylation → up-regulates activity | PAK4 | SIGNOR-275931 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275932 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC7 | SIGNOR-275934 |
| PRKD3 | phosphorylation → down-regulates activity | SSH1 | SIGNOR-275938 |
| PRKD3 | phosphorylation → up-regulates activity | MFF | SIGNOR-275945 |
| PRKD3 | phosphorylation → up-regulates activity | MFF | SIGNOR-275940 |
| PRKD3 | phosphorylation → up-regulates activity | MFF | SIGNOR-275946 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC5 | SIGNOR-275926 |
| PRKD3 | phosphorylation → up-regulates activity | HDAC5 | SIGNOR-275928 |
| PRKD3 | phosphorylation → unknown | GIT1 | SIGNOR-191839 |