| + |
PRKD3 | up-regulates activity 
phosphorylation
|
HDAC7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275932 |
Ser155 |
FPLRKTVsEPNLKLR |
|
|
| pmid |
sentence |
| 18692497 |
Histone deacetylase (HDAC) 5 and 7, two members of the class II of classical HDAC [62], are in vivo substrates of PKD3 and PKD [63]. In response to a variety of signals, including phorbol esters, T cell receptor engagement, vascular endothelial growth factor and angiotensin stimulation, the activity of HDAC5 and 7 are regulated by a mechanism that involves PKD3 and PKD-mediated phosphorylation of the highly conserved Ser259 and Ser498 residues that are located in N-terminus of class II HDACs [63–67]. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275934 |
Ser358 |
WPLSRTRsEPLPPSA |
|
|
| pmid |
sentence |
| 18692497 |
Histone deacetylase (HDAC) 5 and 7, two members of the class II of classical HDAC [62], are in vivo substrates of PKD3 and PKD [63]. In response to a variety of signals, including phorbol esters, T cell receptor engagement, vascular endothelial growth factor and angiotensin stimulation, the activity of HDAC5 and 7 are regulated by a mechanism that involves PKD3 and PKD-mediated phosphorylation of the highly conserved Ser259 and Ser498 residues that are located in N-terminus of class II HDACs [63–67]. |
|
| Publications: |
2 |
| + |
PRKD3 | up-regulates activity
phosphorylation
|
MFF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275945 |
Ser155 |
GRLKRERsMSENAVR |
|
|
| pmid |
sentence |
| 34010649 |
The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cells.|PKD directly phosphorylates MFF on serines 155, 172, and 275 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275940 |
Ser172 |
GQLVRNDsLWHRSDS |
|
|
| pmid |
sentence |
| 34010649 |
The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cells.|PKD directly phosphorylates MFF on serines 155, 172, and 275 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275946 |
Ser275 |
DNVRYGIsNIDTTIE |
|
|
| pmid |
sentence |
| 34010649 |
The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cells.|PKD directly phosphorylates MFF on serines 155, 172, and 275 |
|
| Publications: |
3 |
| + |
PRKD3 | up-regulates activity
phosphorylation
|
HDAC5 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275926 |
Ser259 |
FPLRKTAsEPNLKVR |
|
|
| pmid |
sentence |
| 18692497 |
Histone deacetylase (HDAC) 5 and 7, two members of the class II of classical HDAC [62], are in vivo substrates of PKD3 and PKD [63]. In response to a variety of signals, including phorbol esters, T cell receptor engagement, vascular endothelial growth factor and angiotensin stimulation, the activity of HDAC5 and 7 are regulated by a mechanism that involves PKD3 and PKD-mediated phosphorylation of the highly conserved Ser259 and Ser498 residues that are located in N-terminus of class II HDACs [63–67]. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275928 |
Ser498 |
RPLSRTQsSPLPQSP |
|
|
| pmid |
sentence |
| 18692497 |
Histone deacetylase (HDAC) 5 and 7, two members of the class II of classical HDAC [62], are in vivo substrates of PKD3 and PKD [63]. In response to a variety of signals, including phorbol esters, T cell receptor engagement, vascular endothelial growth factor and angiotensin stimulation, the activity of HDAC5 and 7 are regulated by a mechanism that involves PKD3 and PKD-mediated phosphorylation of the highly conserved Ser259 and Ser498 residues that are located in N-terminus of class II HDACs [63–67]. |
|
| Publications: |
2 |
| + |
PRKD3 |
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Stack trace:
#0 /home/prisca/signor/relation_result.php(2084): implode()
#1 {main}
thrown in /home/prisca/signor/relation_result.php on line 2084
4.0
PRKD3
- 
- 