Entity Details

Name CDK14
ID O94921
Role kinase
Enzymatic Domains
Protein kinase 135-419
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK14LRP6Ser1490AILNPPPsPATERSHphosphorylation
up-regulates		20059949SIGNOR-162924
CDK14TAGLN2Ser163KENPRNFsDNQLQEGphosphorylation
down-regulates activity		21577206SIGNOR-265105
CDK14TAGLN2Ser83PVKKIQAsTMAFKQMphosphorylation
down-regulates activity		21577206SIGNOR-265103
CDK14CCNYSer71RASTIFLsKSQTDVRphosphorylation
down-regulates quantity by destabilization		24794231SIGNOR-273008
CDK14CCNYSer73STIFLSKsQTDVREKphosphorylation
down-regulates quantity by destabilization		24794231SIGNOR-273007
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK14phosphorylation
up-regulates
→
LRP6
PSer1490		phosphorylation
up-regulates
→		LRP620059949SIGNOR-162924
CDK14phosphorylation
up-regulates
→
TAGLN2
PSer163		phosphorylation
down-regulates
⊣		TAGLN221577206SIGNOR-265105
CDK14phosphorylation
up-regulates
→
TAGLN2
PSer83		phosphorylation
down-regulates
⊣		TAGLN221577206SIGNOR-265103
CDK14phosphorylation
up-regulates
→
CCNY
PSer71		phosphorylation
down-regulates
⊣		CCNY24794231SIGNOR-273008
CDK14phosphorylation
up-regulates
→
CCNY
PSer73		phosphorylation
down-regulates
⊣		CCNY24794231SIGNOR-273007
Regulator Mechanism/Effect Target SIGNOR-ID
CDK14phosphorylation
→
up-regulates 		LRP6SIGNOR-162924
CDK14phosphorylation
→
down-regulates activity 		TAGLN2SIGNOR-265105
CDK14phosphorylation
→
down-regulates activity 		TAGLN2SIGNOR-265103
CDK14phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CCNYSIGNOR-273008
CDK14phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		CCNYSIGNOR-273007