Summary

Name CDK14
Full Name Cyclin-dependent kinase 14
Synonyms Cell division protein kinase 14, Serine/threonine-protein kinase PFTAIRE-1, hPFTAIRE1 | KIAA0834, PFTK1
Primary ID O94921
Links - -
Type protein
Relations 2
Function Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.32
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CDK14 0.33
Publications: 1 Organism: Homo Sapiens