| Name | NFATC1 |
| ID | O95644 |
| Role | substrate |
| Enzymatic Domains |
RHD 410-592 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM3 | NFATC1 | – | phosphorylation up-regulates activity | 31730483 | SIGNOR-276773 | |
| PIM1 | NFATC1 | Ser153 | PSSKRSPsTATLSLP | phosphorylation up-regulates activity | 31730483 | SIGNOR-276774 |
| PIM1 | NFATC1 | Ser151 | VLPSSKRsPSTATLS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276779 |
| MAPK10 | NFATC1 | Ser172 | YRDPSCLsPASSLSS | phosphorylation down-regulates | 10652349 | SIGNOR-74556 |
| IKBKE | NFATC1 | Ser151 | VLPSSKRsPSTATLS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276778 |
| DYRK1A | NFATC1 | Ser403 | WAKPKPLsPTSYMSP | phosphorylation up-regulates activity | 28235034 | SIGNOR-278277 |
| PIM1 | NFATC1 | Ser257 | SWLGARSsRPASPCN | phosphorylation up-regulates activity | 31730483 | SIGNOR-276767 |
| JAK3 | NFATC1 | Tyr371 | ADFAPEDySSFQHIR | phosphorylation up-regulates activity | 23263556 | SIGNOR-276435 |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates activity | 23015147 | SIGNOR-253329 | |
| PIM1 | NFATC1 | Ser256 | ESWLGARsSRPASPC | phosphorylation up-regulates activity | 31730483 | SIGNOR-276768 |
| PIM1 | NFATC1 | Ser245 | PSTSPRAsVTEESWL | phosphorylation up-regulates activity | 31730483 | SIGNOR-276770 |
| Calcineurin | NFATC1 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-252323 | |
| MAPK8 | NFATC1 | – | phosphorylation down-regulates activity | 11406366 | SIGNOR-280031 | |
| MAPK14 | NFATC1 | Ser172 | YRDPSCLsPASSLSS | phosphorylation down-regulates | 10652349 | SIGNOR-74560 |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates | 21880741 | SIGNOR-176370 | |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates | 15276472 | SIGNOR-127248 | |
| PIM2 | NFATC1 | – | phosphorylation up-regulates activity | 31730483 | SIGNOR-276772 | |
| DYRK1A | NFATC1 | Ser278 | NGRQPPYsPHHSPTP | phosphorylation up-regulates activity | 28235034 | SIGNOR-278278 |
| PRKCA | NFATC1 | Ser294 | PHGSPRVsVTDDSWL | phosphorylation down-regulates activity | 12351631 | SIGNOR-249175 |
| PIM1 | NFATC1 | Thr339 | PVKSRKTtLEQPPSV | phosphorylation up-regulates activity | 31730483 | SIGNOR-276771 |
| PIM1 | NFATC1 | Ser269 | PCNKRKYsLNGRQPP | phosphorylation up-regulates activity | 31730483 | SIGNOR-276769 |
| Calcineurin | NFATC1 | – | dephosphorylation up-regulates | 14722106 | SIGNOR-252313 | |
| MAPK3 | NFATC1 | Ser172 | YRDPSCLsPASSLSS | phosphorylation down-regulates | 10652349 | SIGNOR-74564 |
| PRKACA | NFATC1 | Ser294 | PHGSPRVsVTDDSWL | phosphorylation down-regulates | 12351631 | SIGNOR-93539 |
| PRKACA | NFATC1 | Ser245 | PSTSPRAsVTEESWL | phosphorylation down-regulates | 12351631 | SIGNOR-93531 |
| PIM1 | NFATC1 | Ser335 | GDGVPVKsRKTTLEQ | phosphorylation up-regulates activity | 31730483 | SIGNOR-276776 |
| DYRK1A | NFATC1 | Ser409 | LSPTSYMsPTLPALD | phosphorylation up-regulates activity | 28235034 | SIGNOR-278276 |
| PRKACA | NFATC1 | Ser269 | PCNKRKYsLNGRQPP | phosphorylation down-regulates | 12351631 | SIGNOR-93535 |
| DYRK1A | NFATC1 | Ser261 | ARSSRPAsPCNKRKY | phosphorylation up-regulates activity | 28235034 | SIGNOR-278279 |
| PIM1 | NFATC1 | Thr154 | SSKRSPStATLSLPS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276777 |
| GSK3B | NFATC1 | – | phosphorylation down-regulates activity | 18675800 | SIGNOR-279185 | |
| PPP3CA | NFATC1 | – | dephosphorylation up-regulates | 14722106 | SIGNOR-84038 | |
| PIM1 | NFATC1 | Thr338 | VPVKSRKtTLEQPPS | phosphorylation up-regulates activity | 31730483 | SIGNOR-276775 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer153 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276774 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer151 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276779 |
| MAPK10 | phosphorylation up-regulates → | NFATC1 PSer172 | phosphorylation down-regulates ⊣ | NFATC1 | 10652349 | SIGNOR-74556 |
| IKBKE | phosphorylation up-regulates → | NFATC1 PSer151 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276778 |
| DYRK1A | phosphorylation up-regulates → | NFATC1 PSer403 | phosphorylation up-regulates → | NFATC1 | 28235034 | SIGNOR-278277 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer257 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276767 |
| JAK3 | phosphorylation up-regulates → | NFATC1 PTyr371 | phosphorylation up-regulates → | NFATC1 | 23263556 | SIGNOR-276435 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer256 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276768 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer245 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276770 |
| MAPK14 | phosphorylation up-regulates → | NFATC1 PSer172 | phosphorylation down-regulates ⊣ | NFATC1 | 10652349 | SIGNOR-74560 |
| DYRK1A | phosphorylation up-regulates → | NFATC1 PSer278 | phosphorylation up-regulates → | NFATC1 | 28235034 | SIGNOR-278278 |
| PRKCA | phosphorylation up-regulates → | NFATC1 PSer294 | phosphorylation down-regulates ⊣ | NFATC1 | 12351631 | SIGNOR-249175 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PThr339 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276771 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer269 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276769 |
| MAPK3 | phosphorylation up-regulates → | NFATC1 PSer172 | phosphorylation down-regulates ⊣ | NFATC1 | 10652349 | SIGNOR-74564 |
| PRKACA | phosphorylation up-regulates → | NFATC1 PSer294 | phosphorylation down-regulates ⊣ | NFATC1 | 12351631 | SIGNOR-93539 |
| PRKACA | phosphorylation up-regulates → | NFATC1 PSer245 | phosphorylation down-regulates ⊣ | NFATC1 | 12351631 | SIGNOR-93531 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer335 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276776 |
| DYRK1A | phosphorylation up-regulates → | NFATC1 PSer409 | phosphorylation up-regulates → | NFATC1 | 28235034 | SIGNOR-278276 |
| PRKACA | phosphorylation up-regulates → | NFATC1 PSer269 | phosphorylation down-regulates ⊣ | NFATC1 | 12351631 | SIGNOR-93535 |
| DYRK1A | phosphorylation up-regulates → | NFATC1 PSer261 | phosphorylation up-regulates → | NFATC1 | 28235034 | SIGNOR-278279 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PThr154 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276777 |
| PIM1 | phosphorylation up-regulates → | NFATC1 PThr338 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276775 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM3 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276773 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276774 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276779 |
| MAPK10 | phosphorylation down-regulates | NFATC1 | SIGNOR-74556 |
| IKBKE | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276778 |
| DYRK1A | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-278277 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276767 |
| JAK3 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276435 |
| PPP3CA | dephosphorylation → up-regulates activity | NFATC1 | SIGNOR-253329 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276768 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276770 |
| Calcineurin | dephosphorylation → up-regulates | NFATC1 | SIGNOR-252323 |
| MAPK8 | phosphorylation → down-regulates activity | NFATC1 | SIGNOR-280031 |
| MAPK14 | phosphorylation down-regulates | NFATC1 | SIGNOR-74560 |
| PPP3CA | dephosphorylation → up-regulates | NFATC1 | SIGNOR-176370 |
| PPP3CA | dephosphorylation → up-regulates | NFATC1 | SIGNOR-127248 |
| PIM2 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276772 |
| DYRK1A | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-278278 |
| PRKCA | phosphorylation → down-regulates activity | NFATC1 | SIGNOR-249175 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276771 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276769 |
| Calcineurin | dephosphorylation → up-regulates | NFATC1 | SIGNOR-252313 |
| MAPK3 | phosphorylation down-regulates | NFATC1 | SIGNOR-74564 |
| PRKACA | phosphorylation down-regulates | NFATC1 | SIGNOR-93539 |
| PRKACA | phosphorylation down-regulates | NFATC1 | SIGNOR-93531 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276776 |
| DYRK1A | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-278276 |
| PRKACA | phosphorylation down-regulates | NFATC1 | SIGNOR-93535 |
| DYRK1A | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-278279 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276777 |
| GSK3B | phosphorylation → down-regulates activity | NFATC1 | SIGNOR-279185 |
| PPP3CA | dephosphorylation → up-regulates | NFATC1 | SIGNOR-84038 |
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276775 |