Summary

Name NFATC1
Full Name Nuclear factor of activated T-cells, cytoplasmic 1
Synonyms NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc | NFAT2, NFATC
Primary ID O95644
Links - -
Type protein
Relations 24
Pathways T cell activation
Function Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NFATC1 0.14
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NFATC1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png dephosphorylation NFATC1 0.34
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/indirect-activation.png T cell activation 0.22
Publications: 1
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding NFATC1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/indirect-activation.png NFATC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation NFATC1 0.59
Publications: 3 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png relocalization NFATC1 0.34
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Skeletal Muscle
+ up-regulates activity img/direct-activation.png dephosphorylation NFATC1 0.59
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH7 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png transcriptional regulation Myotube Hypertrophy 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PLAUR 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization NFATC1 0.49
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle