| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | NFATC1 | Ser245 | PSTSPRAsVTEESWL | phosphorylation up-regulates activity | 31730483 | SIGNOR-276770 |
| PRKACA | NFATC1 | Ser245 | PSTSPRAsVTEESWL | phosphorylation down-regulates | 12351631 | SIGNOR-93531 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PIM1 | phosphorylation up-regulates → | NFATC1 PSer245 | phosphorylation up-regulates → | NFATC1 | 31730483 | SIGNOR-276770 |
| PRKACA | phosphorylation up-regulates → | NFATC1 PSer245 | phosphorylation down-regulates ⊣ | NFATC1 | 12351631 | SIGNOR-93531 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PIM1 | phosphorylation → up-regulates activity | NFATC1 | SIGNOR-276770 |
| PRKACA | phosphorylation down-regulates | NFATC1 | SIGNOR-93531 |
