| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | PTTG1 | Ser89 | KQKQPSFsAKKMTEK | phosphorylation down-regulates quantity by destabilization | 24781523 | SIGNOR-276383 |
| GSK3B | PTTG1 | – | phosphorylation down-regulates activity | 21757741 | SIGNOR-279188 | |
| Gbeta | PTTG1 | – | phosphorylation up-regulates | 10906323 | SIGNOR-270038 | |
| PPP2CA | PTTG1 | Thr66 | ATRKALGtVNRATEK | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276376 |
| PPP2CA | PTTG1 | Ser89 | KQKQPSFsAKKMTEK | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276380 |
| ERK1/2 | PTTG1 | – | phosphorylation up-regulates | 10906323 | SIGNOR-270155 | |
| GSK3B | PTTG1 | Ser184 | NLLQSPSsILSTLDV | phosphorylation down-regulates quantity by destabilization | 21757741 | SIGNOR-276344 |
| CAMK2A | PTTG1 | Ser87 | PLKQKQPsFSAKKMT | phosphorylation down-regulates quantity by destabilization | 24781523 | SIGNOR-276381 |
| GSK3B | PTTG1 | Ser183 | SNLLQSPsSILSTLD | phosphorylation down-regulates quantity by destabilization | 21757741 | SIGNOR-276345 |
| CAMK2A | PTTG1 | Ser31 | LKLGSGPsIKALDGR | phosphorylation down-regulates quantity by destabilization | 24781523 | SIGNOR-276382 |
| PPP2CA | PTTG1 | Ser31 | LKLGSGPsIKALDGR | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276379 |
| MAPK1 | PTTG1 | Ser165 | LFQLGPPsPVKMPSP | phosphorylation up-regulates | 10906323 | SIGNOR-79515 |
| MAPK3 | PTTG1 | Ser165 | LFQLGPPsPVKMPSP | phosphorylation up-regulates | 10906323 | SIGNOR-79519 |
| CAMK2A | PTTG1 | Thr66 | ATRKALGtVNRATEK | phosphorylation down-regulates quantity by destabilization | 24781523 | SIGNOR-276377 |
| PPP2CA | PTTG1 | Ser87 | PLKQKQPsFSAKKMT | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276378 |
| CDK1 | PTTG1 | Ser165 | LFQLGPPsPVKMPSP | phosphorylation up-regulates | 10656688 | SIGNOR-74619 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | PTTG1 PSer89 | phosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276383 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PThr66 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276376 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PSer89 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276380 |
| GSK3B | phosphorylation up-regulates → | PTTG1 PSer184 | phosphorylation down-regulates ⊣ | PTTG1 | 21757741 | SIGNOR-276344 |
| CAMK2A | phosphorylation up-regulates → | PTTG1 PSer87 | phosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276381 |
| GSK3B | phosphorylation up-regulates → | PTTG1 PSer183 | phosphorylation down-regulates ⊣ | PTTG1 | 21757741 | SIGNOR-276345 |
| CAMK2A | phosphorylation up-regulates → | PTTG1 PSer31 | phosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276382 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PSer31 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276379 |
| MAPK1 | phosphorylation up-regulates → | PTTG1 PSer165 | phosphorylation up-regulates → | PTTG1 | 10906323 | SIGNOR-79515 |
| MAPK3 | phosphorylation up-regulates → | PTTG1 PSer165 | phosphorylation up-regulates → | PTTG1 | 10906323 | SIGNOR-79519 |
| CAMK2A | phosphorylation up-regulates → | PTTG1 PThr66 | phosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276377 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PSer87 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276378 |
| CDK1 | phosphorylation up-regulates → | PTTG1 PSer165 | phosphorylation up-regulates → | PTTG1 | 10656688 | SIGNOR-74619 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation down-regulates quantity by destabilization | PTTG1 | SIGNOR-276383 |
| GSK3B | phosphorylation → down-regulates activity | PTTG1 | SIGNOR-279188 |
| Gbeta | phosphorylation → up-regulates | PTTG1 | SIGNOR-270038 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276376 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276380 |
| ERK1/2 | phosphorylation → up-regulates | PTTG1 | SIGNOR-270155 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | PTTG1 | SIGNOR-276344 |
| CAMK2A | phosphorylation down-regulates quantity by destabilization | PTTG1 | SIGNOR-276381 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | PTTG1 | SIGNOR-276345 |
| CAMK2A | phosphorylation down-regulates quantity by destabilization | PTTG1 | SIGNOR-276382 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276379 |
| MAPK1 | phosphorylation → up-regulates | PTTG1 | SIGNOR-79515 |
| MAPK3 | phosphorylation → up-regulates | PTTG1 | SIGNOR-79519 |
| CAMK2A | phosphorylation down-regulates quantity by destabilization | PTTG1 | SIGNOR-276377 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276378 |
| CDK1 | phosphorylation → up-regulates | PTTG1 | SIGNOR-74619 |
