3.0
Summary
| Name |  PTTG1View Modifications |
| Full Name | Securin |
| Synonyms | Esp1-associated protein, Pituitary tumor-transforming gene 1 protein, Tumor-transforming protein 1, hPTTG | EAP1, PTTG, TUTR1 |
| Primary ID | O95997 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK3 | up-regulates 
phosphorylation
|
PTTG1 | 0.31 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK1 | up-regulates
phosphorylation
|
PTTG1 | 0.359 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates
phosphorylation
|
PTTG1 | 0.623 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERK1/2 | up-regulates
phosphorylation
|
PTTG1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTTG1 | down-regulates quantity 
|
TIMP2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTTG1 | up-regulates quantity by expression 
transcriptional regulation
|
LGALS1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | APC-c | down-regulates quantity by destabilization 
ubiquitination
|
PTTG1 | 0.55 |
| Publications: | 1 | |||
| + | Gbeta | up-regulates
phosphorylation
|
PTTG1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTTG1 | up-regulates activity
|
Metastasis | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | PTTG1 | up-regulates quantity by expression
transcriptional regulation
|
S100A4 | 0.276 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTTG1 | down-regulates activity
binding
|
ESPL1 | 0.942 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | UBE4B | down-regulates quantity by destabilization
polyubiquitination
|
PTTG1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |