| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | PTTG1 | Thr66 | ATRKALGtVNRATEK | phosphorylation down-regulates quantity by destabilization | 24781523 | SIGNOR-276377 |
| PPP2CA | PTTG1 | Thr66 | ATRKALGtVNRATEK | dephosphorylation up-regulates quantity by stabilization | 24781523 | SIGNOR-276376 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CAMK2A | phosphorylation up-regulates → | PTTG1 PThr66 | phosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276377 |
| PPP2CA | dephosphorylation down-regulates ⊣ | PTTG1 PThr66 | dephosphorylation down-regulates ⊣ | PTTG1 | 24781523 | SIGNOR-276376 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CAMK2A | phosphorylation![]() down-regulates quantity by destabilization | PTTG1 | SIGNOR-276377 |
| PPP2CA | dephosphorylation → up-regulates quantity by stabilization | PTTG1 | SIGNOR-276376 |