| Name | PAK4 |
| ID | O96013 |
| Role | kinase |
| Enzymatic Domains |
CRIB 11-24 PROSITE-ProRule
Protein kinase 321-572 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK4 | ITGB1BP1 | Ser10 | RKGKKRHsSSSSQSS | phosphorylation down-regulates activity | 32005669 | SIGNOR-280056 |
| PAK4 | SYNJ1 | – | phosphorylation up-regulates activity | 22371566 | SIGNOR-263024 | |
| PAK4 | SNAI2 | Ser158 | CDAQSRKsFSCKYCD | phosphorylation up-regulates quantity by stabilization | 29849120 | SIGNOR-277393 |
| PAK4 | SNAI2 | Ser254 | SKTFSRMsLLHKHEE | phosphorylation up-regulates quantity by stabilization | 29849120 | SIGNOR-277394 |
| PAK4 | SNAI2 | – | phosphorylation up-regulates quantity by stabilization | 30685413 | SIGNOR-280057 | |
| PAK4 | PAK4 | Ser474 | KEVPRRKsLVGTPYW | phosphorylation up-regulates | 20926745 | SIGNOR-168301 |
| PAK4 | PAK4 | Ser474 | KEVPRRKsLVGTPYW | phosphorylation up-regulates activity | 11668177 | SIGNOR-235867 |
| PAK4 | ESR1 | Ser305 | IKRSKKNsLALSLTA | phosphorylation up-regulates activity | 26554417 | SIGNOR-279472 |
| PAK4 | FH | Ser46 | PNAARMAsQNSFRIE | phosphorylation down-regulates quantity | 30683654 | SIGNOR-266315 |
| PAK4 | STMN1 | Ser16 | KELEKRAsGQAFELI | phosphorylation down-regulates activity | 20805321 | SIGNOR-280058 |
| PAK4 | CEBPB | Thr235 | SSSSPPGtPSPADAK | phosphorylation up-regulates activity | 30808546 | SIGNOR-280055 |
| PAK4 | ITGB5 | Ser759 | REFAKFQsERSRARY | phosphorylation up-regulates | 20507994 | SIGNOR-165702 |
| PAK4 | ITGB5 | Ser762 | AKFQSERsRARYEMA | phosphorylation up-regulates | 20507994 | SIGNOR-165706 |
| PAK4 | MZF1 | Ser27 | VMVKLEDsEEEGEAA | phosphorylation up-regulates activity | 30622337 | SIGNOR-277422 |
| PAK4 | CTNNB1 | Ser675 | QDYKKRLsVELTSSL | phosphorylation up-regulates | 22173096 | SIGNOR-191557 |
| PAK4 | PXN | Ser272 | ELDELMAsLSDFKIQ | phosphorylation unknown | 20406887 | SIGNOR-164889 |
| PAK4 | RAN | Ser135 | DRKVKAKsIVFHRKK | phosphorylation unknown | 20805321 | SIGNOR-167671 |
| PAK4 | RAN | Ser135 | DRKVKAKsIVFHRKK | phosphorylation up-regulates | 20805321 | SIGNOR-167667 |
| PAK4 | SMAD2 | Ser465 | SPSVRCSsMS | phosphorylation down-regulates quantity by destabilization | 23934187 | SIGNOR-279084 |
| PAK4 | NFE2L2 | Thr369 | ESSSYGDtLLGLSDS | phosphorylation down-regulates quantity by destabilization | 35108418 | SIGNOR-277583 |
| PAK4 | ARHGEF2 | – | phosphorylation down-regulates activity | 23125951 | SIGNOR-279245 | |
| PAK4 | PACSIN1 | Ser346 | SQAGDRGsVSSYDRG | phosphorylation up-regulates activity | 22371566 | SIGNOR-263023 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PAK4 | phosphorylation up-regulates → | ITGB1BP1 PSer10 | phosphorylation down-regulates ⊣ | ITGB1BP1 | 32005669 | SIGNOR-280056 |
| PAK4 | phosphorylation up-regulates → | SNAI2 PSer158 | phosphorylation up-regulates → | SNAI2 | 29849120 | SIGNOR-277393 |
| PAK4 | phosphorylation up-regulates → | SNAI2 PSer254 | phosphorylation up-regulates → | SNAI2 | 29849120 | SIGNOR-277394 |
| PAK4 | phosphorylation up-regulates → | PAK4 PSer474 | phosphorylation up-regulates → | PAK4 | 20926745 | SIGNOR-168301 |
| PAK4 | phosphorylation up-regulates → | PAK4 PSer474 | phosphorylation up-regulates → | PAK4 | 11668177 | SIGNOR-235867 |
| PAK4 | phosphorylation up-regulates → | ESR1 PSer305 | phosphorylation up-regulates → | ESR1 | 26554417 | SIGNOR-279472 |
| PAK4 | phosphorylation up-regulates → | FH PSer46 | phosphorylation down-regulates ⊣ | FH | 30683654 | SIGNOR-266315 |
| PAK4 | phosphorylation up-regulates → | STMN1 PSer16 | phosphorylation down-regulates ⊣ | STMN1 | 20805321 | SIGNOR-280058 |
| PAK4 | phosphorylation up-regulates → | CEBPB PThr235 | phosphorylation up-regulates → | CEBPB | 30808546 | SIGNOR-280055 |
| PAK4 | phosphorylation up-regulates → | ITGB5 PSer759 | phosphorylation up-regulates → | ITGB5 | 20507994 | SIGNOR-165702 |
| PAK4 | phosphorylation up-regulates → | ITGB5 PSer762 | phosphorylation up-regulates → | ITGB5 | 20507994 | SIGNOR-165706 |
| PAK4 | phosphorylation up-regulates → | MZF1 PSer27 | phosphorylation up-regulates → | MZF1 | 30622337 | SIGNOR-277422 |
| PAK4 | phosphorylation up-regulates → | CTNNB1 PSer675 | phosphorylation up-regulates → | CTNNB1 | 22173096 | SIGNOR-191557 |
| PAK4 | phosphorylation up-regulates → | PXN PSer272 | phosphorylation down-regulates ⊣ | PXN | 20406887 | SIGNOR-164889 |
| PAK4 | phosphorylation up-regulates → | RAN PSer135 | phosphorylation down-regulates ⊣ | RAN | 20805321 | SIGNOR-167671 |
| PAK4 | phosphorylation up-regulates → | RAN PSer135 | phosphorylation up-regulates → | RAN | 20805321 | SIGNOR-167667 |
| PAK4 | phosphorylation up-regulates → | SMAD2 PSer465 | phosphorylation down-regulates ⊣ | SMAD2 | 23934187 | SIGNOR-279084 |
| PAK4 | phosphorylation up-regulates → | NFE2L2 PThr369 | phosphorylation down-regulates ⊣ | NFE2L2 | 35108418 | SIGNOR-277583 |
| PAK4 | phosphorylation up-regulates → | PACSIN1 PSer346 | phosphorylation up-regulates → | PACSIN1 | 22371566 | SIGNOR-263023 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PAK4 | phosphorylation → down-regulates activity | ITGB1BP1 | SIGNOR-280056 |
| PAK4 | phosphorylation → up-regulates activity | SYNJ1 | SIGNOR-263024 |
| PAK4 | phosphorylation → up-regulates quantity by stabilization | SNAI2 | SIGNOR-277393 |
| PAK4 | phosphorylation → up-regulates quantity by stabilization | SNAI2 | SIGNOR-277394 |
| PAK4 | phosphorylation → up-regulates quantity by stabilization | SNAI2 | SIGNOR-280057 |
| PAK4 | phosphorylation → up-regulates | PAK4 | SIGNOR-168301 |
| PAK4 | phosphorylation → up-regulates activity | PAK4 | SIGNOR-235867 |
| PAK4 | phosphorylation → up-regulates activity | ESR1 | SIGNOR-279472 |
| PAK4 | phosphorylation → down-regulates quantity | FH | SIGNOR-266315 |
| PAK4 | phosphorylation → down-regulates activity | STMN1 | SIGNOR-280058 |
| PAK4 | phosphorylation → up-regulates activity | CEBPB | SIGNOR-280055 |
| PAK4 | phosphorylation → up-regulates | ITGB5 | SIGNOR-165702 |
| PAK4 | phosphorylation → up-regulates | ITGB5 | SIGNOR-165706 |
| PAK4 | phosphorylation → up-regulates activity | MZF1 | SIGNOR-277422 |
| PAK4 | phosphorylation → up-regulates | CTNNB1 | SIGNOR-191557 |
| PAK4 | phosphorylation → unknown | PXN | SIGNOR-164889 |
| PAK4 | phosphorylation → unknown | RAN | SIGNOR-167671 |
| PAK4 | phosphorylation → up-regulates | RAN | SIGNOR-167667 |
| PAK4 | phosphorylation down-regulates quantity by destabilization | SMAD2 | SIGNOR-279084 |
| PAK4 | phosphorylation down-regulates quantity by destabilization | NFE2L2 | SIGNOR-277583 |
| PAK4 | phosphorylation → down-regulates activity | ARHGEF2 | SIGNOR-279245 |
| PAK4 | phosphorylation → up-regulates activity | PACSIN1 | SIGNOR-263023 |