Summary

Name PAK4
Full Name Serine/threonine-protein kinase PAK 4
Synonyms p21-activated kinase 4, PAK-4 | KIAA1142
Primary ID O96013
Links - -
Type protein
Relations 8
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation RAN 0.41
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAN 0.41
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation PXN 0.52
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PAK4
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PAK4
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation CTNNB1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ITGB5 0.60
Publications: 2 Organism: Homo Sapiens