| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | ALDH1A1 | Thr267 | KSNLKRVtLELGGKS | phosphorylation up-regulates quantity | 28193222 | SIGNOR-278166 |
| AURKA | ALDH1A1 | Thr442 | KDIDKAItISSALQA | phosphorylation up-regulates quantity | 28193222 | SIGNOR-278167 |
| CDK5 | ALDH1A1 | Ser75 | RQAFQIGsPWRTMDA | phosphorylation up-regulates quantity | 29948941 | SIGNOR-279400 |
| AURKA | ALDH1A1 | Thr493 | YTEVKTVtVKISQKN | phosphorylation up-regulates activity | 28193222 | SIGNOR-276749 |
| AURKA | ALDH1A1 | Thr493 | YTEVKTVtVKISQKN | phosphorylation up-regulates quantity | 28193222 | SIGNOR-278165 |
| AURKA | ALDH1A1 | Thr442 | KDIDKAItISSALQA | phosphorylation up-regulates activity | 28193222 | SIGNOR-276748 |
| CDK5 | ALDH1A1 | Ser274 | TLELGGKsPCIVLAD | phosphorylation up-regulates quantity | 29948941 | SIGNOR-279399 |
| AURKA | ALDH1A1 | Thr267 | KSNLKRVtLELGGKS | phosphorylation up-regulates activity | 28193222 | SIGNOR-276750 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr267 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-278166 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr442 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-278167 |
| CDK5 | phosphorylation up-regulates → | ALDH1A1 PSer75 | phosphorylation up-regulates → | ALDH1A1 | 29948941 | SIGNOR-279400 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr493 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-276749 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr493 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-278165 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr442 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-276748 |
| CDK5 | phosphorylation up-regulates → | ALDH1A1 PSer274 | phosphorylation up-regulates → | ALDH1A1 | 29948941 | SIGNOR-279399 |
| AURKA | phosphorylation up-regulates → | ALDH1A1 PThr267 | phosphorylation up-regulates → | ALDH1A1 | 28193222 | SIGNOR-276750 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-278166 |
| AURKA | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-278167 |
| CDK5 | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-279400 |
| AURKA | phosphorylation → up-regulates activity | ALDH1A1 | SIGNOR-276749 |
| AURKA | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-278165 |
| AURKA | phosphorylation → up-regulates activity | ALDH1A1 | SIGNOR-276748 |
| CDK5 | phosphorylation → up-regulates quantity | ALDH1A1 | SIGNOR-279399 |
| AURKA | phosphorylation → up-regulates activity | ALDH1A1 | SIGNOR-276750 |
