| + |
EZH2 | down-regulates quantity by repression 
transcriptional regulation
|
ALDH1A1 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254141 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 22144423 |
For three selected genes (ALDH1A1, SSTR1, and DACT3), we validated their upregulation upon EZH2 knockdown and confirmed the binding of EZH2/H3K27Me3 to their genomic loci. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDH1A1 | down-regulates quantity 
chemical modification
|
retinal |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265122 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21621639 |
All-trans-retinoic acid (atRA) provides essential support to diverse biological systems and physiological processes.| An accrual of biochemical, physiological and genetic data have identified specific functional outcomes for the retinol dehydrogenases, RDH1, RDH10, and DHRS9, as physiological catalysts of the first step in atRA biosynthesis, and for the retinal dehydrogenases RALDH1, RALDH2, and RALDH3, as catalysts of the second and irreversible step. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic Acid Metabolism |
| + |
ALDH1A1 | up-regulates quantity 
chemical modification
|
all-trans-retinoic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21621639 |
All-trans-retinoic acid (atRA) provides essential support to diverse biological systems and physiological processes.| An accrual of biochemical, physiological and genetic data have identified specific functional outcomes for the retinol dehydrogenases, RDH1, RDH10, and DHRS9, as physiological catalysts of the first step in atRA biosynthesis, and for the retinal dehydrogenases RALDH1, RALDH2, and RALDH3, as catalysts of the second and irreversible step. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic Acid Metabolism |
3.0
ALDH1A1
- 
- 