| Name | FOS |
| ID | P01100 |
| Role | substrate |
| Enzymatic Domains |
bZIP 137-200 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 1545828 | SIGNOR-250356 |
| RPS6K | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-252789 |
| MAPK1 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 12972619 | SIGNOR-236010 |
| RPS6K | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 16055710 | SIGNOR-262998 |
| ERK1/2 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 16055710 | SIGNOR-263009 |
| MAPK3 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 12972619 | SIGNOR-118031 |
| MAPK1 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 12972619 | SIGNOR-236014 |
| MAPK1 | FOS | Thr232 | GGLPEVAtPESEEAF | phosphorylation up-regulates activity | 7816602 | SIGNOR-235877 |
| ERK1/2 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 12972619 | SIGNOR-251523 |
| RPS6KA1 | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 16055710 | SIGNOR-262999 |
| RPS6KA4 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-37216 |
| RPS6KA1 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-37154 |
| RPS6KA4 | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 16055710 | SIGNOR-263000 |
| MAPK3 | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 12972619 | SIGNOR-118023 |
| MAPK3 | FOS | Thr232 | GGLPEVAtPESEEAF | phosphorylation up-regulates | 7816602 | SIGNOR-33909 |
| MAPK1 | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 12972619 | SIGNOR-235671 |
| RPS6KA4 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 22187936 | SIGNOR-191678 |
| ERK1/2 | FOS | – | phosphorylation up-regulates | 21561061 | SIGNOR-260762 | |
| ERK1/2 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 16055710 | SIGNOR-263010 |
| ERK1/2 | FOS | Thr232 | GGLPEVAtPESEEAF | phosphorylation up-regulates | 7816602 | SIGNOR-251525 |
| ERK1/2 | FOS | Ser374 | PSSDSLSsPTLLAL | phosphorylation up-regulates activity | 12972619 | SIGNOR-251524 |
| MAPK1 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 16055710 | SIGNOR-262996 |
| MAPK3 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 12972619 | SIGNOR-118027 |
| ERK1/2 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 16055710 | SIGNOR-262995 |
| Gbeta | FOS | – | phosphorylation up-regulates | 7816602 | SIGNOR-270105 | |
| MAPK3 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 16055710 | SIGNOR-263012 |
| MAPK3 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 16055710 | SIGNOR-262997 |
| MAPK1 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 16055710 | SIGNOR-263011 |
| MAPK1 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 16055710 | SIGNOR-263007 |
| ERK1/2 | FOS | Thr325 | TELEPLCtPVVTCTP | phosphorylation up-regulates activity | 12972619 | SIGNOR-251522 |
| MAPK3 | FOS | Thr331 | CTPVVTCtPSCTAYT | phosphorylation up-regulates activity | 16055710 | SIGNOR-263008 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 1545828 | SIGNOR-250356 |
| RPS6K | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-252789 |
| MAPK1 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-236010 |
| RPS6K | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262998 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263009 |
| MAPK3 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-118031 |
| MAPK1 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-236014 |
| MAPK1 | phosphorylation up-regulates → | FOS PThr232 | phosphorylation up-regulates → | FOS | 7816602 | SIGNOR-235877 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-251523 |
| RPS6KA1 | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262999 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-37216 |
| RPS6KA1 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-37154 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263000 |
| MAPK3 | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-118023 |
| MAPK3 | phosphorylation up-regulates → | FOS PThr232 | phosphorylation up-regulates → | FOS | 7816602 | SIGNOR-33909 |
| MAPK1 | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-235671 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 22187936 | SIGNOR-191678 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263010 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr232 | phosphorylation up-regulates → | FOS | 7816602 | SIGNOR-251525 |
| ERK1/2 | phosphorylation up-regulates → | FOS PSer374 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-251524 |
| MAPK1 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262996 |
| MAPK3 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-118027 |
| ERK1/2 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262995 |
| MAPK3 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263012 |
| MAPK3 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262997 |
| MAPK1 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263011 |
| MAPK1 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263007 |
| ERK1/2 | phosphorylation up-regulates → | FOS PThr325 | phosphorylation up-regulates → | FOS | 12972619 | SIGNOR-251522 |
| MAPK3 | phosphorylation up-regulates → | FOS PThr331 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-263008 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates activity | FOS | SIGNOR-250356 |
| RPS6K | phosphorylation → up-regulates activity | FOS | SIGNOR-252789 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-236010 |
| RPS6K | phosphorylation → up-regulates activity | FOS | SIGNOR-262998 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-263009 |
| MAPK3 | phosphorylation → up-regulates activity | FOS | SIGNOR-118031 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-236014 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-235877 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-251523 |
| RPS6KA1 | phosphorylation → up-regulates activity | FOS | SIGNOR-262999 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-37216 |
| RPS6KA1 | phosphorylation → up-regulates activity | FOS | SIGNOR-37154 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-263000 |
| MAPK3 | phosphorylation → up-regulates activity | FOS | SIGNOR-118023 |
| MAPK3 | phosphorylation → up-regulates | FOS | SIGNOR-33909 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-235671 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-191678 |
| ERK1/2 | phosphorylation → up-regulates | FOS | SIGNOR-260762 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-263010 |
| ERK1/2 | phosphorylation → up-regulates | FOS | SIGNOR-251525 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-251524 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-262996 |
| MAPK3 | phosphorylation → up-regulates activity | FOS | SIGNOR-118027 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-262995 |
| Gbeta | phosphorylation → up-regulates | FOS | SIGNOR-270105 |
| MAPK3 | phosphorylation → up-regulates activity | FOS | SIGNOR-263012 |
| MAPK3 | phosphorylation → up-regulates activity | FOS | SIGNOR-262997 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-263011 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-263007 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-251522 |
| MAPK3 | phosphorylation → up-regulates activity | FOS | SIGNOR-263008 |