Summary

Name FOS
Full Name Proto-oncogene c-Fos
Synonyms Cellular oncogene fos, G0/G1 switch regulatory protein 7 | G0S7
Primary ID P01100
Links - -
Type protein
Relations 54
Pathways Acute Myeloid Leukemia, miRNA in AML, EGFR Signaling, Leptin Signaling
Function Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png sumoylation FOS 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png sumoylation FOS 0.373
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.2
Publications: 6 Organism: , Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Leptin Signaling, T cell activation
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.2
Publications: 2 Organism: Homo Sapiens,
Pathways:Leptin Signaling
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.505
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.4
Publications: 3 Organism: Homo Sapiens,
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.542
Publications: 2 Organism: Homo Sapiens,
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.783
Publications: 7 Organism: , Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.704
Publications: 6 Organism: , Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOS 0.704
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOS 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, EGFR Signaling, Leptin Signaling, T cell activation
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOS 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png post transcriptional regulation FOS 0.297
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation FOS 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.491
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOS 0.706
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding AP1 0.951
Publications: 4 Organism: Homo Sapiens, In Vitro
Pathways:Acute Myeloid Leukemia, miRNA in AML, Leptin Signaling, T cell activation
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FOS 0.2
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png binding JUN 0.951
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, EGFR Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.645
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOS 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CYP19A1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HSD3B2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png FOS 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FOS 0.4
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation FOS 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FOS 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.325
Publications: 1
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation STAR 0.26
Publications: 1 Organism: Homo Sapiens