Summary

Name FOS
Full Name Proto-oncogene c-Fos
Synonyms Cellular oncogene fos, G0/G1 switch regulatory protein 7 | G0S7
Primary ID P01100
Links - -
Type protein
Relations 33
Pathways EGFR, T cell activation
Function Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation FOS 0.09
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOS
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png phosphorylation FOS
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation FOS 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation FOS
Publications: 4 Organism: Homo Sapiens
Pathways:EGFR, T cell activation
+ up-regulates img/direct-activation.png phosphorylation FOS 0.32
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation FOS 0.38
Publications: 4 Organism: Homo Sapiens
+ form complex img/form-complex.png binding AP1
Publications: 4 Organism: In Vitro, Homo Sapiens
Pathways:T cell activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CYP19A1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation STAR 0.10
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation FOS
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FOS 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png post transcriptional regulation FOS
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.05
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FOS 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding JUN 0.99
Publications: 1 Organism: Mus Musculus
Pathways:EGFR
+ up-regulates img/indirect-activation.png unknown FOS
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOS
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation HSD3B2 0.14
Publications: 1 Organism: Homo Sapiens