| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 1545828 | SIGNOR-250356 |
| RPS6K | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-252789 |
| MAPK3 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 16055710 | SIGNOR-262997 |
| RPS6KA4 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-37216 |
| RPS6KA1 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 8248197 | SIGNOR-37154 |
| RPS6KA4 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 22187936 | SIGNOR-191678 |
| MAPK1 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 16055710 | SIGNOR-262996 |
| ERK1/2 | FOS | Ser362 | AAAHRKGsSSNEPSS | phosphorylation up-regulates activity | 16055710 | SIGNOR-262995 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKACA | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 1545828 | SIGNOR-250356 |
| RPS6K | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-252789 |
| MAPK3 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262997 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-37216 |
| RPS6KA1 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 8248197 | SIGNOR-37154 |
| RPS6KA4 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 22187936 | SIGNOR-191678 |
| MAPK1 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262996 |
| ERK1/2 | phosphorylation up-regulates → | FOS PSer362 | phosphorylation up-regulates → | FOS | 16055710 | SIGNOR-262995 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKACA | phosphorylation → up-regulates activity | FOS | SIGNOR-250356 |
| RPS6K | phosphorylation → up-regulates activity | FOS | SIGNOR-252789 |
| MAPK3 | phosphorylation → up-regulates activity | FOS | SIGNOR-262997 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-37216 |
| RPS6KA1 | phosphorylation → up-regulates activity | FOS | SIGNOR-37154 |
| RPS6KA4 | phosphorylation → up-regulates activity | FOS | SIGNOR-191678 |
| MAPK1 | phosphorylation → up-regulates activity | FOS | SIGNOR-262996 |
| ERK1/2 | phosphorylation → up-regulates activity | FOS | SIGNOR-262995 |
