Entity Details

Name KRAS
ID P01116
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN2KRAS–dephosphorylation
down-regulates activity		33122197SIGNOR-277039
SRCKRAS–phosphorylation
up-regulates		9096340SIGNOR-47152
SRCKRASTyr64DTAGQEEySAMRDQYphosphorylation
up-regulates activity		34725361SIGNOR-278991
SRCKRASTyr32QNHFVDEyDPTIEDSphosphorylation
up-regulates activity		34725361SIGNOR-278990
PTPN11KRASTyr32QNHFVDEyDPTIEDSdephosphorylation
up-regulates activity		26617336SIGNOR-255982
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SRCphosphorylation
up-regulates
→
KRAS
PTyr64		phosphorylation
up-regulates
→		KRAS34725361SIGNOR-278991
SRCphosphorylation
up-regulates
→
KRAS
PTyr32		phosphorylation
up-regulates
→		KRAS34725361SIGNOR-278990
PTPN11dephosphorylation
down-regulates
⊣
KRAS
PTyr32		dephosphorylation
down-regulates
⊣		KRAS26617336SIGNOR-255982
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN2dephosphorylation
→
down-regulates activity 		KRASSIGNOR-277039
SRCphosphorylation
→
up-regulates 		KRASSIGNOR-47152
SRCphosphorylation
→
up-regulates activity 		KRASSIGNOR-278991
SRCphosphorylation
→
up-regulates activity 		KRASSIGNOR-278990
PTPN11dephosphorylation
→
up-regulates activity 		KRASSIGNOR-255982