Relation Results

Summary

Name KRAS
Full Name GTPase KRas
Synonyms K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras | KRAS2, RASK2
Primary ID P01116
Links - -
Type protein
Relations 44
Pathways Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, COVID-19 Causal Network, Colorectal Carcinoma, FLT3-ITD signaling, Glioblastoma Multiforme, GPCR_CRC, Luminal Breast Cancer, LIF in PDAC, Macropinocytosis , Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma, SARS-CoV MAPK PERTURBATION, Thyroid cancer
Function Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (Pu ...
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Type: Score: Layout: SPV 
0.2510.6590.6890.4320.5140.4280.3670.6570.7760.20.7210.70.630.7110.20.4180.8270.4230.910.2730.2970.20.20.6470.420.8460.7380.3550.8760.20.3830.7120.2770.2670.280.20.20.595LZTR1KRASPTPN11RASSF5RAPGEF5DAB2IPNFE2L2MAP3K1SRCPIK3CGNFIL3NF1GlycolysisPIK3CDSOS2EFR3ARAP1GDS1SOS1RASGEF1APIK3CACARM1RASGEF1BEML4-ALKMAP4K5RASSF1FNTBRAF1PI3KAv/b3 integrinBRAFRASGEF1CFNTAPIK3CBPTPN2TRiCV-ATPaseMVDMINK1RIN1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ LZTR1down-regulates activity img/direct_inhibition.png ubiquitination KRAS 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-269068 Lys170 IRQYRLKkISKEEKT Homo sapiens HEK-293 Cell
pmid sentence
By trapping LZTR1 complexes from intact mammalian cells, we identified the guanosine triphosphatase RAS as a substrate for the LZTR1-CUL3 complex. Ubiquitome analysis showed that loss of Lztr1 abrogated Ras ubiquitination at lysine-170. LZTR1-mediated ubiquitination inhibited RAS signaling by attenuating its association with the membrane.
Publications: 1 Organism: Homo Sapiens
+ PTPN11up-regulates activity img/direct-activation.png dephosphorylation KRAS 0.659
Identifier Residue Sequence Organism Cell Line
SIGNOR-255982 Tyr32 QNHFVDEyDPTIEDS Homo sapiens HEK-293 Cell
pmid sentence
Here we identify SHP2 as the ubiquitously expressed tyrosine phosphatase that preferentially binds to and dephosphorylates Ras to increase its association with Raf and activate downstream proliferative Ras/ERK/MAPK signalling.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD signaling, Noonan syndrome
+ RASSF5up-regulates activity img/direct-activation.png binding KRAS 0.689
Identifier Residue Sequence Organism Cell Line
SIGNOR-249586 Homo sapiens
pmid sentence
NORE1A can bind K-Ras.GTP through its RA domain and regulate the proapoptotic activity of MST1/2 kinases
Publications: 1 Organism: Homo Sapiens
+ RAPGEF5up-regulates img/direct-activation.png guanine nucleotide exchange factor KRAS 0.432
Identifier Residue Sequence Organism Cell Line
SIGNOR-183735 Homo sapiens
pmid sentence
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras.
Publications: 1 Organism: Homo Sapiens
+ DAB2IPdown-regulates activity img/direct_inhibition.png gtpase-activating protein KRAS 0.514
Identifier Residue Sequence Organism Cell Line
SIGNOR-254746 Homo sapiens
pmid sentence
The GAP domain of DAB2IP is homologous to other Ras-GAPs, such as GAP120 and neurofibromin (NF1), and can stimulate the GTPase activity of RAS proteins both in vitro and in cancer cell lines. DAB2IP is able to stimulate in vitro and in vivo the GTPase activity of RAS proteins (H-Ras, K-Ras, and N-Ras) facilitating GTP hydrolysis to GDP.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFE2L2 0.428
Identifier Residue Sequence Organism Cell Line
SIGNOR-267361 Homo sapiens
pmid sentence
Oncogenic proteins that regulate proliferation, such as KRAS, BRAF, and MYC increase the transcription of NRF2
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates img/direct-activation.png binding MAP3K1 0.367
Identifier Residue Sequence Organism Cell Line
SIGNOR-32620 Homo sapiens
pmid sentence
Mitogen-activated protein kinase kinase kinase (mekk1) is a serine-threonine kinase that regulates sequential protein kinase pathways involving stress-activated protein kinases and mitogen-activated protein kinases. Mekk1 is activated in response to growth factor stimulation of cells and by expression of activated ras. mekk1 directly binds ras.GTP. Thus, ras interacts with protein kinases of both the raf and mekk families.
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ SRCup-regulates img/direct-activation.png phosphorylation KRAS 0.657
Identifier Residue Sequence Organism Cell Line
SIGNOR-47152 Homo sapiens
pmid sentence
Expression of v-src, a transforming nonreceptor tyrosine kinase, results in ras activation, and ras function in nih 3t3 cells suppresses transformation by v-src, indicating that in these cells ras-dependent signaling pathways are required for v-src to exert its biological effects.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ KRASup-regulates img/direct-activation.png binding PIK3CG 0.776
Identifier Residue Sequence Organism Cell Line
SIGNOR-175213 Homo sapiens
pmid sentence
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner.
Identifier Residue Sequence Organism Cell Line
SIGNOR-59819 Homo sapiens
pmid sentence
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner.
Publications: 2 Organism: Homo Sapiens
+ KRASup-regulates img/indirect-activation.png NFIL3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-242757 Mus musculus Pro-B-lymphocyte
pmid sentence
A constitutively active Ras protein [Ras(G12V)] regulates the stable expression of the NFIL3 transcription factor through both the Raf-MAPK and PI3-K pathways.
Publications: 1 Organism: Mus Musculus
+ NF1down-regulates activity img/direct_inhibition.png binding KRAS 0.721
Identifier Residue Sequence Organism Cell Line
SIGNOR-273661 Homo sapiens HEK-293 Cell
pmid sentence
Sprouty-related, EVH1 domain-containing (SPRED) proteins negatively regulate RAS/mitogen-activated protein kinase (MAPK) signaling following growth factor stimulation. This inhibition of RAS is thought to occur primarily through SPRED1 binding and recruitment of neurofibromin, a RasGAP, to the plasma membrane. Here, we report the structure of neurofibromin (GTPase-activating protein [GAP]-related domain) complexed with SPRED1 (EVH1 domain) and KRAS. The structure provides insight into how the membrane targeting of neurofibromin by SPRED1 allows simultaneous interaction with activated KRAS.
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ KRASup-regulates img/indirect-activation.png Glycolysis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259372 Homo sapiens Colonic Cancer Cell Line
pmid sentence
These alterations corresponded to mutant KRAS and BRAF-dependent increases in glucose uptake and lactate production. Metabolic reprogramming and glucose conversion to lactate in RKO cells were proportional to levels of BRAF V600E protein.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates img/direct-activation.png binding PIK3CD 0.63
Identifier Residue Sequence Organism Cell Line
SIGNOR-175210 Homo sapiens
pmid sentence
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k
Publications: 1 Organism: Homo Sapiens
+ SOS2up-regulates img/direct-activation.png guanine nucleotide exchange factor KRAS 0.711
Identifier Residue Sequence Organism Cell Line
SIGNOR-175265 Homo sapiens
pmid sentence
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85.
Publications: 1 Organism: Homo Sapiens
+ EFR3Aup-regulates quantity img/direct-activation.png binding KRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269094 Homo sapiens HEK-293 Cell
pmid sentence
EFR3A directly binds to active KRAS through its C-terminus. EFR3A promotes the localization and nanoclustering of KRAS at the plasma membrane.
Publications: 1 Organism: Homo Sapiens
+ RAP1GDS1up-regulates img/direct-activation.png binding KRAS 0.418
Identifier Residue Sequence Organism Cell Line
SIGNOR-171415 Homo sapiens
pmid sentence
Smggds has been previously shown to activate a wide variety of small gtpases, including the ras family members rap1a, rap1b, and k-ras, as well as the rho family members cdc42, rac1, rac2, rhoa, and rhob
Publications: 1 Organism: Homo Sapiens
+ SOS1up-regulates img/direct-activation.png guanine nucleotide exchange factor KRAS 0.827
Identifier Residue Sequence Organism Cell Line
SIGNOR-122075 Homo sapiens
pmid sentence
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts
Identifier Residue Sequence Organism Cell Line
SIGNOR-201703 Homo sapiens
pmid sentence
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts
Identifier Residue Sequence Organism Cell Line
SIGNOR-175256 Homo sapiens
pmid sentence
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts
Identifier Residue Sequence Organism Cell Line
SIGNOR-141647 Homo sapiens
pmid sentence
Because the KRAS-GDP to KRAS-GTP transition catalyzed by the GEF, son of sevenless 1 (SOS1), represents the rate-limiting step for nucleotide exchange, disrupting the activating SOS1/KRAS protein interaction has also been the focus of drug development efforts
Publications: 4 Organism: Homo Sapiens
Pathways:Adipogenesis, Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, COVID-19 Causal Network, Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Rhabdomyosarcoma, SARS-CoV MAPK PERTURBATION, Thyroid cancer
+ LZTR1down-regulates quantity img/direct_inhibition.png ubiquitination KRAS 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-269069 Homo sapiens HEK-293 Cell
pmid sentence
We demonstrate that LZTR1 facilitates the polyubiquitination and degradation of RAS via the ubiquitin-proteasome pathway, leading to the inhibition of the RAS/MAPK signaling.
Publications: 1 Organism: Homo Sapiens
+ RASGEF1Aup-regulates img/direct-activation.png guanine nucleotide exchange factor KRAS 0.423
Identifier Residue Sequence Organism Cell Line
SIGNOR-183826 Homo sapiens
pmid sentence
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates img/direct-activation.png binding PIK3CA 0.91
Identifier Residue Sequence Organism Cell Line
SIGNOR-175204 Homo sapiens
pmid sentence
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k phosphatidylinositol 3-kinase (pi3k) is one of the main effector pathways of ras, regulating cell growth, cell cycle entry, cell survival, cytoskeleton reorganization, and metabolism.
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Glioblastoma Multiforme, Luminal Breast Cancer, Rhabdomyosarcoma
+ KRASdown-regulates activity img/indirect_inhibition.png CARM1 0.273
Identifier Residue Sequence Organism Cell Line
SIGNOR-267640 Homo sapiens PANC-1 Cell
pmid sentence
Interestingly, overexpression of KRASG12V (an activating mutant) in BxPC-3 cells, a PDAC cell line carrying wild-type KRAS, led to a 40% decrease of CARM1 protein and consequent hypomethylation or activation of MDH1|These observations indicate that KRAS suppresses CARM1-mediated MDH1 methylation, contributing to Gln metabolism in pancreatic cancer.
Publications: 1 Organism: Homo Sapiens
+ RASGEF1Bup-regulates img/direct-activation.png binding KRAS 0.297
Identifier Residue Sequence Organism Cell Line
SIGNOR-183835 Homo sapiens
pmid sentence
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras.
Publications: 1 Organism: Homo Sapiens
+ EML4-ALKup-regulates img/indirect-activation.png KRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253216 Homo sapiens
pmid sentence
A recurrent gene fusion between echinoderm microtubule-associated protein-like 4 (EML4;and, occasionally, of other fusion partners) and the anaplastic lymphoma kinase (ALK) geneoccurs in of NSCLCs , resulting in activation of a potent ALK fusion protein.ALK fusion protein is usually found in never-smoker subjects. Although relatively rare, therelative paucity of fusion proteins known to contribute to lung cancer pathogenesis makes this a finding of biological interest. Although present understanding of the ALK fusion protein is limited, it may play a role in activating RAS. Thus it is negatively associated with thepresence of KRAS or EGFR mutations, and may favour ADC histology and never-smokerstatus.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates img/indirect-activation.png MAP4K5 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-64262 Homo sapiens Leukemia Cell
pmid sentence
Bcr-abl_mediated ras activation is crucial for the ability of bcr-abl to activate gckr and is consistent with the previously known requirement for ras in bcr-abl_induced sapk activation how ras activates gckr remains enigmatic.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates activity img/direct-activation.png binding RASSF1 0.647
Identifier Residue Sequence Organism Cell Line
SIGNOR-249585 Homo sapiens
pmid sentence
Mutant K-Ras promotes MST2 activation in two ways (i.e., by direct disruption of the inhibitory Raf-1-MST2 complex (Matallanas et al., 2008) and by forming an activating (i.e., by direct disruption of the inhibitory Raf-1-MST2 complex K-Ras-RASSF1A€“MST2 complex, as reported here
Publications: 1 Organism: Homo Sapiens
Pathways:Non-small-cell lung cancer (NSCLC)
+ FNTBup-regulates activity img/direct-activation.png KRAS 0.42
Identifier Residue Sequence Organism Cell Line
SIGNOR-242556 Homo sapiens
pmid sentence
Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates img/direct-activation.png binding RAF1 0.846
Identifier Residue Sequence Organism Cell Line
SIGNOR-78911 Homo sapiens
pmid sentence
Among other effectors, active ras binds and activates the raf kinase, iniziating a kinase cascade involving serine phosporylation of mek1/2 (mapkk) and tyrosine and threonine phosphorylation of erk1/2. the raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases.. Association of ras with the mapk kinase kinase, raf, initiates the raf mek erk map kinase cascade.
Identifier Residue Sequence Organism Cell Line
SIGNOR-141641 Homo sapiens
pmid sentence
Among other effectors, active ras binds and activates the raf kinase, iniziating a kinase cascade involving serine phosporylation of mek1/2 (mapkk) and tyrosine and threonine phosphorylation of erk1/2. the raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases.. Association of ras with the mapk kinase kinase, raf, initiates the raf mek erk map kinase cascade.
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, COVID-19 Causal Network, Noonan syndrome, SARS-CoV MAPK PERTURBATION
+ KRASup-regulates img/direct-activation.png binding PI3K 0.738
Identifier Residue Sequence Organism Cell Line
SIGNOR-252698 Homo sapiens
pmid sentence
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k phosphatidylinositol 3-kinase (pi3k) is one of the main effector pathways of ras, regulating cell growth, cell cycle entry, cell survival, cytoskeleton reorganization, and metabolism.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, COVID-19 Causal Network, FLT3-ITD signaling, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA)
+ Av/b3 integrinup-regulates activity img/direct-activation.png binding KRAS 0.355
Identifier Residue Sequence Organism Cell Line
SIGNOR-277742 Homo sapiens Pancreatic Cancer Cell
pmid sentence
Oncogenic RAS requires a protein scaffold to induce downstream signaling and macropinocytosis, three separate studies have identified upstream and downstream regulators that help drive this process in cancer cells. Anchorage-independent growth of cancer cells is supported by avb3 integrins which can be clustered by the extracellular lectin, galectin-3 to drive mutant RAS-mediated macropinocytosis for nutrient supplementation and growth of anchorage-independent cells. Secreted galectin-3 was found to bind to the N-glycans on surface avb3 integrins, clustering the integrins on the surface of the nonadherent cells for the recruitment of mutant KRAS as a signaling platform for inducing macropinocytosis.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates activity img/direct-activation.png binding BRAF 0.876
Identifier Residue Sequence Organism Cell Line
SIGNOR-156906 Homo sapiens
pmid sentence
The raf family of proteins (raf-1, a-raf, and b-raf) is serine/threonine kinases that bind to the effector region of ras-gtp, thus inducing translocation of the protein to the plasma membrane. Once there, raf proteins are activated and phosphorylated by different protein kinases.
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, Colorectal Carcinoma, FLT3-ITD signaling, Glioblastoma Multiforme, Luminal Breast Cancer, Noonan syndrome, Non-small-cell lung cancer (NSCLC), Pancreatic ductal adenocarcinoma (PDA), Rhabdomyosarcoma, Thyroid cancer
+ RASGEF1Cup-regulates img/direct-activation.png binding KRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-161508 Homo sapiens
pmid sentence
Gefs catalyse the transition from gdp-bound, inactive ras to gtp-bound, active ras.
Publications: 1 Organism: Homo Sapiens
+ FNTAup-regulates activity img/direct-activation.png KRAS 0.383
Identifier Residue Sequence Organism Cell Line
SIGNOR-242559 Homo sapiens
pmid sentence
Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials.
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates img/direct-activation.png binding PIK3CB 0.712
Identifier Residue Sequence Organism Cell Line
SIGNOR-175207 Homo sapiens
pmid sentence
Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k.
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ PTPN2down-regulates activity img/direct_inhibition.png dephosphorylation KRAS 0.277
Identifier Residue Sequence Organism Cell Line
SIGNOR-277039 Homo sapiens
pmid sentence
Mechanistically, PTPN2 negatively regulates tyrosine phosphorylation of KRAS, which, in turn, affects the activation KRAS and its downstream signaling.
Publications: 1 Organism: Homo Sapiens
+ TRiCup-regulates quantity by stabilization img/direct-activation.png binding KRAS 0.267
Identifier Residue Sequence Organism Cell Line
SIGNOR-272871 Homo sapiens
pmid sentence
Mammalian cells contain an evolutionarily conserved type II chaperonin called chaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC). The CCT complex is composed of eight subunits [CCT1-8 (yeast) or CCTα-θ (mammals)] and folds substrates needed for cell invasion and proliferation, such as actin, tubulin, and cell division cycle protein 20 homolog (cdc20), as well as oncoproteins like signal transducer and activator of transcription 3 (STAT3), Kirsten rat sarcoma viral oncogene homolog (KRAS), and Myelocytomatosis (MYC).
Publications: 1 Organism: Homo Sapiens
+ KRASup-regulates activity img/direct-activation.png relocalization V-ATPase 0.28
Identifier Residue Sequence Organism Cell Line
SIGNOR-277759 Homo sapiens Pancreatic Cancer Cell
pmid sentence
V-ATPase is required for macropinocytosis. oncogenic RAS-dependent recruitment of V-ATPase to the plasma membrane constitutes an essential step in induction of macropinocytosis. Here we identify vacuolar ATPase (V-ATPase) as an essential regulator of RAS-induced macropinocytosis. Oncogenic RAS promotes the translocation of V-ATPase from intracellular membranes to the plasma membrane via a pathway that requires the activation of protein kinase A by a bicarbonate- dependent soluble adenylate cyclase.
Publications: 1 Organism: Homo Sapiens
+ MVDup-regulates quantity by stabilization img/indirect-activation.png KRAS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265887 Chlorocebus aethiops
pmid sentence
An overexpression of mot-2 resulted in reduced level of Ras and phosphorylated ERK2. These were rescued by co-expression of MPD from an exogenous promoter demonstrating a functional link between mot-2, MPD, and Ras. Ras and its oncogenic forms act as key players in controlling proliferation of normal and cancerous cells. Assigning mot-2 upstream of p21Ras offers an important mechanism for influence over cell proliferation. Therefore, we ra tionaled to investigate if overexpression of MPD could affect the steady state levels of Ras by affecting its prenylationTransient transfections of MPD-myc in COS 7 cells resulted in higher stable levels of Ras as compared to the untransfected cells (Fig. 3A, compare lanes 4 and 8 and Fig. 3B)
Publications: 1 Organism: Chlorocebus Aethiops
+ KRASup-regulates img/indirect-activation.png MINK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-142985 Homo sapiens
pmid sentence
Mink is activated after ras induction via a mechanism involving reactive oxygen species and mediates stimulation of the stress-activated protein kinase p38 mapk downstream of the raf/erk pathway.
Publications: 1 Organism: Homo Sapiens
+ RIN1up-regulates img/direct-activation.png binding KRAS 0.595
Identifier Residue Sequence Organism Cell Line
SIGNOR-113970 Homo sapiens
pmid sentence
We demonstrate that the ras effector protein rin1 binds to activated ras with an affinity (k(d), 22 nm) similar to that observed for raf1.
Publications: 1 Organism: Homo Sapiens
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