| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | KRAS | Tyr32 | QNHFVDEyDPTIEDS | phosphorylation up-regulates activity | 34725361 | SIGNOR-278990 |
| PTPN11 | KRAS | Tyr32 | QNHFVDEyDPTIEDS | dephosphorylation up-regulates activity | 26617336 | SIGNOR-255982 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SRC | phosphorylation up-regulates → | KRAS PTyr32 | phosphorylation up-regulates → | KRAS | 34725361 | SIGNOR-278990 |
| PTPN11 | dephosphorylation down-regulates ⊣ | KRAS PTyr32 | dephosphorylation down-regulates ⊣ | KRAS | 26617336 | SIGNOR-255982 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SRC | phosphorylation → up-regulates activity | KRAS | SIGNOR-278990 |
| PTPN11 | dephosphorylation → up-regulates activity | KRAS | SIGNOR-255982 |
