| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | MBP | Ser190 | RGAPKRGsGKDSHHP | phosphorylation unknown | 2413024 | SIGNOR-248871 |
| MAPK1 | MBP | Thr232 | KNIVTPRtPPPSQGK | phosphorylation down-regulates | 1939237 | SIGNOR-22420 |
| PRKACA | MBP | Ser141 | MASQKRPsQRHGSKY | phosphorylation unknown | 2413024 | SIGNOR-250010 |
| PRKCA | MBP | Ser266 | FGYGGRAsDYKSAHK | phosphorylation unknown | 2413024 | SIGNOR-248873 |
| PRKCA | MBP | Ser285 | VDAQGTLsKIFKLGG | phosphorylation unknown | 2413024 | SIGNOR-248874 |
| MAPK3 | MBP | Thr232 | KNIVTPRtPPPSQGK | phosphorylation down-regulates | 16401070 | SIGNOR-143481 |
| PRKACA | MBP | Thr169 | FLPRHRDtGILDSIG | phosphorylation unknown | 2413024 | SIGNOR-250015 |
| Gbeta | MBP | – | phosphorylation down-regulates | 16401070 | SIGNOR-270100 | |
| PRKCA | MBP | Ser295 | FKLGGRDsRSGSPMA | phosphorylation unknown | 2413024 | SIGNOR-248875 |
| UHMK1 | MBP | Ser299 | GRDSRSGsPMARR | phosphorylation down-regulates | 16401070 | SIGNOR-143485 |
| ERK1/2 | MBP | – | phosphorylation down-regulates | 16401070 | SIGNOR-270195 | |
| PRKACA | MBP | Ser146 | RPSQRHGsKYLATAS | phosphorylation unknown | 2413024 | SIGNOR-250011 |
| PRKACA | MBP | Ser295 | FKLGGRDsRSGSPMA | phosphorylation unknown | 2413024 | SIGNOR-250014 |
| PRKCA | MBP | Ser249 | GLSLSRFsWGAEGQR | phosphorylation unknown | 2413024 | SIGNOR-248872 |
| PRKACA | MBP | Ser266 | FGYGGRAsDYKSAHK | phosphorylation unknown | 2413024 | SIGNOR-250013 |
| PRKACA | MBP | Ser190 | RGAPKRGsGKDSHHP | phosphorylation unknown | 2413024 | SIGNOR-250012 |
| UHMK1 | MBP | Ser299 | GRDSRSGsPMARR | phosphorylation down-regulates | 10880969 | SIGNOR-78895 |
| PRKCA | MBP | Ser141 | MASQKRPsQRHGSKY | phosphorylation unknown | 2413024 | SIGNOR-248869 |
| MAPK1 | MBP | Thr229 | HFFKNIVtPRTPPPS | phosphorylation unknown | 12760422 | SIGNOR-249419 |
| PRKCA | MBP | Ser146 | RPSQRHGsKYLATAS | phosphorylation unknown | 2413024 | SIGNOR-248870 |
| MAPK1 | MBP | Thr232 | KNIVTPRtPPPSQGK | phosphorylation down-regulates | 16401070 | SIGNOR-143477 |
| MAPK3 | MBP | Thr232 | KNIVTPRtPPPSQGK | phosphorylation down-regulates | 1939237 | SIGNOR-22424 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | MBP PSer190 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-248871 |
| MAPK1 | phosphorylation up-regulates → | MBP PThr232 | phosphorylation down-regulates ⊣ | MBP | 1939237 | SIGNOR-22420 |
| PRKACA | phosphorylation up-regulates → | MBP PSer141 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-250010 |
| PRKCA | phosphorylation up-regulates → | MBP PSer266 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-248873 |
| PRKCA | phosphorylation up-regulates → | MBP PSer285 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-248874 |
| MAPK3 | phosphorylation up-regulates → | MBP PThr232 | phosphorylation down-regulates ⊣ | MBP | 16401070 | SIGNOR-143481 |
| PRKACA | phosphorylation up-regulates → | MBP PThr169 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-250015 |
| PRKCA | phosphorylation up-regulates → | MBP PSer295 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-248875 |
| UHMK1 | phosphorylation up-regulates → | MBP PSer299 | phosphorylation down-regulates ⊣ | MBP | 16401070 | SIGNOR-143485 |
| PRKACA | phosphorylation up-regulates → | MBP PSer146 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-250011 |
| PRKACA | phosphorylation up-regulates → | MBP PSer295 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-250014 |
| PRKCA | phosphorylation up-regulates → | MBP PSer249 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-248872 |
| PRKACA | phosphorylation up-regulates → | MBP PSer266 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-250013 |
| PRKACA | phosphorylation up-regulates → | MBP PSer190 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-250012 |
| UHMK1 | phosphorylation up-regulates → | MBP PSer299 | phosphorylation down-regulates ⊣ | MBP | 10880969 | SIGNOR-78895 |
| PRKCA | phosphorylation up-regulates → | MBP PSer141 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-248869 |
| MAPK1 | phosphorylation up-regulates → | MBP PThr229 | phosphorylation down-regulates ⊣ | MBP | 12760422 | SIGNOR-249419 |
| PRKCA | phosphorylation up-regulates → | MBP PSer146 | phosphorylation down-regulates ⊣ | MBP | 2413024 | SIGNOR-248870 |
| MAPK1 | phosphorylation up-regulates → | MBP PThr232 | phosphorylation down-regulates ⊣ | MBP | 16401070 | SIGNOR-143477 |
| MAPK3 | phosphorylation up-regulates → | MBP PThr232 | phosphorylation down-regulates ⊣ | MBP | 1939237 | SIGNOR-22424 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → unknown | MBP | SIGNOR-248871 |
| MAPK1 | phosphorylation![]() down-regulates | MBP | SIGNOR-22420 |
| PRKACA | phosphorylation → unknown | MBP | SIGNOR-250010 |
| PRKCA | phosphorylation → unknown | MBP | SIGNOR-248873 |
| PRKCA | phosphorylation → unknown | MBP | SIGNOR-248874 |
| MAPK3 | phosphorylation![]() down-regulates | MBP | SIGNOR-143481 |
| PRKACA | phosphorylation → unknown | MBP | SIGNOR-250015 |
| Gbeta | phosphorylation![]() down-regulates | MBP | SIGNOR-270100 |
| PRKCA | phosphorylation → unknown | MBP | SIGNOR-248875 |
| UHMK1 | phosphorylation![]() down-regulates | MBP | SIGNOR-143485 |
| ERK1/2 | phosphorylation![]() down-regulates | MBP | SIGNOR-270195 |
| PRKACA | phosphorylation → unknown | MBP | SIGNOR-250011 |
| PRKACA | phosphorylation → unknown | MBP | SIGNOR-250014 |
| PRKCA | phosphorylation → unknown | MBP | SIGNOR-248872 |
| PRKACA | phosphorylation → unknown | MBP | SIGNOR-250013 |
| PRKACA | phosphorylation → unknown | MBP | SIGNOR-250012 |
| UHMK1 | phosphorylation![]() down-regulates | MBP | SIGNOR-78895 |
| PRKCA | phosphorylation → unknown | MBP | SIGNOR-248869 |
| MAPK1 | phosphorylation → unknown | MBP | SIGNOR-249419 |
| PRKCA | phosphorylation → unknown | MBP | SIGNOR-248870 |
| MAPK1 | phosphorylation![]() down-regulates | MBP | SIGNOR-143477 |
| MAPK3 | phosphorylation![]() down-regulates | MBP | SIGNOR-22424 |