Summary

Name MBP
Full Name Myelin basic protein
Synonyms MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein
Primary ID P02686
Links - -
Type protein
Relations 20
Function The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation MBP 0.14
Publications: 7 Organism: In Vitro
+ img/unknown.png phosphorylation MBP 0.14
Publications: 6 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation MBP 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.2
Publications: 2 Organism: Homo Sapiens
Tissue: Brain
+ down-regulates img/direct_inhibition.png phosphorylation MBP 0.28
Publications: 2 Organism: Homo Sapiens
Tissue: Brain