Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
RAF1	PPP1R12A	–		phosphorylation down-regulates activity	22225925	SIGNOR-278979
RAF1	RAF1	Thr268	PNVHMVStTLPVDSR	phosphorylation unknown	8349614	SIGNOR-248917
RAF1	RAF1	Ser621 View in OncoXplorer	PKINRSAsEPSLHRA	phosphorylation up-regulates activity	19595761	SIGNOR-235770
RAF1	RB1	–		phosphorylation down-regulates activity	9819434	SIGNOR-279481
RAF1	MAP2K2	Ser222	VSGQLIDsMANSFVG	phosphorylation up-regulates	8157000	SIGNOR-262292
RAF1	MAP2K2	Ser226	LIDSMANsFVGTRSY	phosphorylation up-regulates	8157000	SIGNOR-36553
RAF1	XIAP	–		phosphorylation up-regulates activity	16964381	SIGNOR-279105
RAF1	MAP2K1	Ser218	VSGQLIDsMANSFVG	phosphorylation up-regulates activity	10359597	SIGNOR-235987
RAF1	MAP2K1	Ser222	LIDSMANsFVGTRSY	phosphorylation up-regulates activity	10359597	SIGNOR-235991
RAF1	EEF1A2	Ser21	GHVDSGKsTTTGHLI	phosphorylation down-regulates quantity by destabilization	22378069	SIGNOR-276407
RAF1	KLF10	Thr93	TIPAFCLtPPYSPSD	phosphorylation down-regulates quantity by destabilization	23994618	SIGNOR-276502
RAF1	BAD	Ser75	EIRSRHSsYPAGTED	phosphorylation down-regulates	15849194	SIGNOR-81165
RAF1	BAD	Ser118	GRELRRMsDEFVDSF	phosphorylation down-regulates	17535812	SIGNOR-155293
RAF1	MEK1/2	–		phosphorylation up-regulates	11018021	SIGNOR-244952
RAF1	MEK1/2	–		phosphorylation up-regulates activity	11018021	SIGNOR-244945

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
RAF1	phosphorylation up-regulates →	RAF1 PThr268	phosphorylation down-regulates ⊣	RAF1	8349614	SIGNOR-248917
RAF1	phosphorylation up-regulates →	RAF1 PSer621	phosphorylation up-regulates →	RAF1	19595761	SIGNOR-235770
RAF1	phosphorylation up-regulates →	MAP2K2 PSer222	phosphorylation up-regulates →	MAP2K2	8157000	SIGNOR-262292
RAF1	phosphorylation up-regulates →	MAP2K2 PSer226	phosphorylation up-regulates →	MAP2K2	8157000	SIGNOR-36553
RAF1	phosphorylation up-regulates →	MAP2K1 PSer218	phosphorylation up-regulates →	MAP2K1	10359597	SIGNOR-235987
RAF1	phosphorylation up-regulates →	MAP2K1 PSer222	phosphorylation up-regulates →	MAP2K1	10359597	SIGNOR-235991
RAF1	phosphorylation up-regulates →	EEF1A2 PSer21	phosphorylation down-regulates ⊣	EEF1A2	22378069	SIGNOR-276407
RAF1	phosphorylation up-regulates →	KLF10 PThr93	phosphorylation down-regulates ⊣	KLF10	23994618	SIGNOR-276502
RAF1	phosphorylation up-regulates →	BAD PSer75	phosphorylation down-regulates ⊣	BAD	15849194	SIGNOR-81165
RAF1	phosphorylation up-regulates →	BAD PSer118	phosphorylation down-regulates ⊣	BAD	17535812	SIGNOR-155293

Regulator	Mechanism/Effect	Target	SIGNOR-ID
RAF1	phosphorylation → down-regulates activity	PPP1R12A	SIGNOR-278979
RAF1	phosphorylation → unknown	RAF1	SIGNOR-248917
RAF1	phosphorylation → up-regulates activity	RAF1	SIGNOR-235770
RAF1	phosphorylation → down-regulates activity	RB1	SIGNOR-279481
RAF1	phosphorylation → up-regulates	MAP2K2	SIGNOR-262292
RAF1	phosphorylation → up-regulates	MAP2K2	SIGNOR-36553
RAF1	phosphorylation → up-regulates activity	XIAP	SIGNOR-279105
RAF1	phosphorylation → up-regulates activity	MAP2K1	SIGNOR-235987
RAF1	phosphorylation → up-regulates activity	MAP2K1	SIGNOR-235991
RAF1	phosphorylation down-regulates quantity by destabilization	EEF1A2	SIGNOR-276407
RAF1	phosphorylation down-regulates quantity by destabilization	KLF10	SIGNOR-276502
RAF1	phosphorylation down-regulates	BAD	SIGNOR-81165
RAF1	phosphorylation down-regulates	BAD	SIGNOR-155293
RAF1	phosphorylation → up-regulates	MEK1/2	SIGNOR-244952
RAF1	phosphorylation → up-regulates activity	MEK1/2	SIGNOR-244945