Summary

Name RAF1
Full Name RAF proto-oncogene serine/threonine-protein kinase
Synonyms Proto-oncogene c-RAF, cRaf, Raf-1 | RAF
Primary ID P04049
Links - -
Type protein
Relations 96
Pathways Insulin Receptor, Adipogenesis, Noonan syndrome, Integrin Signalling
Inhibitors Raf265 derivative; 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine; 3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxo-6-quinazolinyl)amino]phenyl]benzamide; 2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol; sorafenib; 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide; ZM 336372; regorafenib; sorafenib tosylate; dabrafenib
Function Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation BAD 0.42
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K1 0.58
Publications: 2 Organism: Homo Sapiens
Tissue: Ovary
+ up-regulates img/direct-activation.png phosphorylation MAP2K2 0.58
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.2
Publications: 3 Organism: Chlorocebus Aethiops
+ img/unknown.png phosphorylation RAF1 0.28
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.31
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Myotube
Pathways:Insulin Receptor, Integrin Signalling
+ up-regulates activity img/direct-activation.png dephosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.53
Publications: 3 Organism: Homo Sapiens
Tissue: Muscle, Myotube
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.59
Publications: 6 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.47
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.22
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Receptor, Integrin Signalling, Noonan syndrome
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.56
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.28
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Receptor, Integrin Signalling, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.46
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation RAF1 0.44
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation RAF1 0.34
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.34
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RAF1 0.31
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Adipogenesis, Insulin Receptor, Integrin Signalling, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RAF1 0.31
Publications: 1 Organism: In Vitro
Pathways:Adipogenesis, Insulin Receptor, Integrin Signalling, Noonan syndrome
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.23
Publications: 4 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates activity img/direct-activation.png phosphorylation RAF1 0.14
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding RAF1 0.7
Publications: 2 Organism: Homo Sapiens
Pathways:Insulin Receptor, Integrin Signalling, Noonan syndrome
+ up-regulates activity img/direct-activation.png phosphorylation MEK1/2 0.28
Publications: 1 Organism: Homo Sapiens
Tissue: Ovary
Pathways:Adipogenesis, Insulin Receptor, Integrin Signalling, Noonan syndrome
+ up-regulates img/direct-activation.png binding RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RAF1 0.59
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAF1 0.59
Publications: 2 Organism: Homo Sapiens
Pathways:Adipogenesis, Noonan syndrome
+ up-regulates img/direct-activation.png binding RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation RAF1 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation RAF1 0.34
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ down-regulates img/direct_inhibition.png binding RAF1 0.52
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RAF1 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RAF1 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MEK1/2 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis, Insulin Receptor, Integrin Signalling, Noonan syndrome
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP3K5 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding STK4 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition RAF1 0.14
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png binding STK3 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RAF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png relocalization RAF1 0.45
Publications: 1 Organism: Homo Sapiens
Pathways:Noonan syndrome