| Name | RAF1 |
| ID | P04049 |
| Role | substrate |
| Enzymatic Domains |
RBD 56-131 PROSITE-ProRule
Protein kinase 349-609 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation down-regulates | 9091312 | SIGNOR-47148 |
| MAPK1 | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates activity | 15664191 | SIGNOR-249439 |
| MAPK3 | RAF1 | Ser296 | SPSALSSsPNNLSPT | phosphorylation down-regulates activity | 15664191 | SIGNOR-143692 |
| MAPK1 | RAF1 | Ser301 | SSSPNNLsPTGWSQP | phosphorylation down-regulates activity | 15664191 | SIGNOR-249443 |
| MAP2K1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 23360980 | SIGNOR-279627 |
| PRKCG | RAF1 | Ser619 | SLPKINRsASEPSLH | phosphorylation up-regulates | 8288587 | SIGNOR-37545 |
| Gbeta | RAF1 | – | phosphorylation down-regulates | 16407412 | SIGNOR-270010 | |
| AKT | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 10576741 | SIGNOR-72669 |
| PRKACA | RAF1 | Ser233 | VSSQHRYsTPHAFTF | phosphorylation down-regulates activity | 12801936 | SIGNOR-250040 |
| AKT2 | RAF1 | – | phosphorylation down-regulates activity | 10576742 | SIGNOR-235678 | |
| PDPK1 | RAF1 | – | phosphorylation up-regulates activity | 29575487 | SIGNOR-280063 | |
| MAPK3 | RAF1 | – | phosphorylation down-regulates | 9922370 | SIGNOR-64172 | |
| PLK1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 27003818 | SIGNOR-278190 |
| PRKCA | RAF1 | Ser619 | SLPKINRsASEPSLH | phosphorylation up-regulates | 12551925 | SIGNOR-97648 |
| AKT1 | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 16854453 | SIGNOR-147963 |
| ERK1/2 | RAF1 | Ser289 | RSHSESAsPSALSSS | phosphorylation down-regulates activity | 15664191 | SIGNOR-244677 |
| AMPK | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 11971957 | SIGNOR-216523 |
| AKT | RAF1 | – | phosphorylation down-regulates | 14967450 | SIGNOR-244333 | |
| CDC25A | RAF1 | – | dephosphorylation down-regulates | 7744247 | SIGNOR-32548 | |
| PKN1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 11733498 | SIGNOR-112549 |
| PRKCA | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates | 7935389 | SIGNOR-34761 |
| SRC | RAF1 | Tyr340 | RGQRDSSyYWEIEAS | phosphorylation up-regulates | 7692235 | SIGNOR-32081 |
| PRKACA | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates | 11971957 | SIGNOR-86145 |
| MAPK3 | RAF1 | Ser289 | RSHSESAsPSALSSS | phosphorylation down-regulates activity | 15664191 | SIGNOR-143688 |
| MAPK1 | RAF1 | Ser29 | FDGSSCIsPTIVQQF | phosphorylation down-regulates activity | 15664191 | SIGNOR-249441 |
| PRKCG | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation up-regulates | 8288587 | SIGNOR-37541 |
| MAPK1 | RAF1 | Ser642 | NACTLTTsPRLPVF | phosphorylation down-regulates activity | 15664191 | SIGNOR-249444 |
| ERK1/2 | RAF1 | – | phosphorylation down-regulates | 9922370 | SIGNOR-244688 | |
| PRKACA | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates activity | 12801936 | SIGNOR-250039 |
| PAK3 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 9823899 | SIGNOR-62043 |
| JAK2 | RAF1 | Tyr340 | RGQRDSSyYWEIEAS | phosphorylation up-regulates activity | 8876196 | SIGNOR-251361 |
| RAF1 | RAF1 | Thr268 | PNVHMVStTLPVDSR | phosphorylation unknown | 8349614 | SIGNOR-248917 |
| PRKCB | RAF1 | Ser619 | SLPKINRsASEPSLH | phosphorylation up-regulates | 8288587 | SIGNOR-37478 |
| PRKACA | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 11971957 | SIGNOR-86141 |
| ERK1/2 | RAF1 | Ser296 | SPSALSSsPNNLSPT | phosphorylation down-regulates activity | 15664191 | SIGNOR-244681 |
| MAPK1 | RAF1 | Ser296 | SPSALSSsPNNLSPT | phosphorylation down-regulates activity | 15664191 | SIGNOR-249442 |
| PAK6 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 18465753 | SIGNOR-278971 |
| KSR1 | RAF1 | Thr269 | NVHMVSTtLPVDSRM | phosphorylation up-regulates | 11134016 | SIGNOR-85386 |
| AKT | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 16854453 | SIGNOR-244337 |
| PAK1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates | 18775988 | SIGNOR-180812 |
| ERK1/2 | RAF1 | Ser301 | SSSPNNLsPTGWSQP | phosphorylation down-regulates | 16407412 | SIGNOR-244685 |
| RAF1 | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation up-regulates activity | 19595761 | SIGNOR-235770 |
| SRC | RAF1 | Tyr340 | RGQRDSSyYWEIEAS | phosphorylation up-regulates | 12551923 | SIGNOR-97635 |
| PRKCA | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation up-regulates | 8288587 | SIGNOR-37470 |
| PRKCA | RAF1 | Ser233 | VSSQHRYsTPHAFTF | phosphorylation unknown | 12551925 | SIGNOR-37466 |
| MAPK1 | RAF1 | Ser289 | RSHSESAsPSALSSS | phosphorylation down-regulates activity | 15664191 | SIGNOR-249440 |
| PLK1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates activity | 27003818 | SIGNOR-278191 |
| PRKCA | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation unknown | 12551925 | SIGNOR-37844 |
| PP2Ca_R1A_Bd | RAF1 | Ser259 | SQRQRSTsTPNVHMV | dephosphorylation up-regulates activity | 16239230 | SIGNOR-243538 |
| PAK1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 18775988 | SIGNOR-180808 |
| PPP5C | RAF1 | Ser338 | RPRGQRDsSYYWEIE | dephosphorylation down-regulates activity | 16892053 | SIGNOR-248537 |
| SRC | RAF1 | Tyr341 | GQRDSSYyWEIEASE | phosphorylation up-regulates | 12551923 | SIGNOR-97639 |
| PHLPP1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | dephosphorylation down-regulates activity | 24530606 | SIGNOR-237449 |
| PP2CA_R1A_R2A | RAF1 | Ser259 | SQRQRSTsTPNVHMV | dephosphorylation up-regulates activity | 16239230 | SIGNOR-243534 |
| PRKACA | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation down-regulates activity | 11971957 | SIGNOR-86137 |
| MAPK3 | RAF1 | – | phosphorylation down-regulates | 15664191 | SIGNOR-133345 | |
| PPP1CA | RAF1 | Ser259 | SQRQRSTsTPNVHMV | dephosphorylation up-regulates activity | 16630891 | SIGNOR-251649 |
| PRKAA1 | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 11971957 | SIGNOR-86133 |
| PRKCB | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation up-regulates | 8288587 | SIGNOR-37474 |
| AKT1 | RAF1 | – | phosphorylation down-regulates | 22798428 | SIGNOR-252531 | |
| PRKACA | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates activity | 12801936 | SIGNOR-250041 |
| PKN1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates | 15849194 | SIGNOR-135679 |
| PRKCA | RAF1 | Ser499 | VKSRWSGsQQVEQPT | phosphorylation unknown | 12551925 | SIGNOR-97644 |
| AMPK | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation up-regulates | 9091312 | SIGNOR-216616 |
| PPP2CA | RAF1 | – | dephosphorylation up-regulates | 16239230 | SIGNOR-141170 | |
| MAPK1 | RAF1 | – | phosphorylation down-regulates | 9922370 | SIGNOR-64169 | |
| MAPK3 | RAF1 | Ser301 | SSSPNNLsPTGWSQP | phosphorylation down-regulates | 16407412 | SIGNOR-143696 |
| SRC | RAF1 | Tyr340 | RGQRDSSyYWEIEAS | phosphorylation up-regulates | 10998357 | SIGNOR-82150 |
| AKT1 | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 10576741 | SIGNOR-252588 |
| JAK2 | RAF1 | Tyr341 | GQRDSSYyWEIEASE | phosphorylation up-regulates activity | 8876196 | SIGNOR-251362 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA1 | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation down-regulates ⊣ | RAF1 | 9091312 | SIGNOR-47148 |
| MAPK1 | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-249439 |
| MAPK3 | phosphorylation up-regulates → | RAF1 PSer296 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-143692 |
| MAPK1 | phosphorylation up-regulates → | RAF1 PSer301 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-249443 |
| MAP2K1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 23360980 | SIGNOR-279627 |
| PRKCG | phosphorylation up-regulates → | RAF1 PSer619 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37545 |
| AKT | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 10576741 | SIGNOR-72669 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer233 | phosphorylation down-regulates ⊣ | RAF1 | 12801936 | SIGNOR-250040 |
| PLK1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 27003818 | SIGNOR-278190 |
| PRKCA | phosphorylation up-regulates → | RAF1 PSer619 | phosphorylation up-regulates → | RAF1 | 12551925 | SIGNOR-97648 |
| AKT1 | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 16854453 | SIGNOR-147963 |
| ERK1/2 | phosphorylation up-regulates → | RAF1 PSer289 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-244677 |
| AMPK | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-216523 |
| PKN1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 11733498 | SIGNOR-112549 |
| PRKCA | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 7935389 | SIGNOR-34761 |
| SRC | phosphorylation up-regulates → | RAF1 PTyr340 | phosphorylation up-regulates → | RAF1 | 7692235 | SIGNOR-32081 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86145 |
| MAPK3 | phosphorylation up-regulates → | RAF1 PSer289 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-143688 |
| MAPK1 | phosphorylation up-regulates → | RAF1 PSer29 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-249441 |
| PRKCG | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37541 |
| MAPK1 | phosphorylation up-regulates → | RAF1 PSer642 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-249444 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 12801936 | SIGNOR-250039 |
| PAK3 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 9823899 | SIGNOR-62043 |
| JAK2 | phosphorylation up-regulates → | RAF1 PTyr340 | phosphorylation up-regulates → | RAF1 | 8876196 | SIGNOR-251361 |
| RAF1 | phosphorylation up-regulates → | RAF1 PThr268 | phosphorylation down-regulates ⊣ | RAF1 | 8349614 | SIGNOR-248917 |
| PRKCB | phosphorylation up-regulates → | RAF1 PSer619 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37478 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86141 |
| ERK1/2 | phosphorylation up-regulates → | RAF1 PSer296 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-244681 |
| MAPK1 | phosphorylation up-regulates → | RAF1 PSer296 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-249442 |
| PAK6 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 18465753 | SIGNOR-278971 |
| KSR1 | phosphorylation up-regulates → | RAF1 PThr269 | phosphorylation up-regulates → | RAF1 | 11134016 | SIGNOR-85386 |
| AKT | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 16854453 | SIGNOR-244337 |
| PAK1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 18775988 | SIGNOR-180812 |
| ERK1/2 | phosphorylation up-regulates → | RAF1 PSer301 | phosphorylation down-regulates ⊣ | RAF1 | 16407412 | SIGNOR-244685 |
| RAF1 | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation up-regulates → | RAF1 | 19595761 | SIGNOR-235770 |
| SRC | phosphorylation up-regulates → | RAF1 PTyr340 | phosphorylation up-regulates → | RAF1 | 12551923 | SIGNOR-97635 |
| PRKCA | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37470 |
| PRKCA | phosphorylation up-regulates → | RAF1 PSer233 | phosphorylation down-regulates ⊣ | RAF1 | 12551925 | SIGNOR-37466 |
| MAPK1 | phosphorylation up-regulates → | RAF1 PSer289 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-249440 |
| PLK1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 27003818 | SIGNOR-278191 |
| PRKCA | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation down-regulates ⊣ | RAF1 | 12551925 | SIGNOR-37844 |
| PP2Ca_R1A_Bd | dephosphorylation down-regulates ⊣ | RAF1 PSer259 | dephosphorylation down-regulates ⊣ | RAF1 | 16239230 | SIGNOR-243538 |
| PAK1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 18775988 | SIGNOR-180808 |
| PPP5C | dephosphorylation down-regulates ⊣ | RAF1 PSer338 | dephosphorylation up-regulates → | RAF1 | 16892053 | SIGNOR-248537 |
| SRC | phosphorylation up-regulates → | RAF1 PTyr341 | phosphorylation up-regulates → | RAF1 | 12551923 | SIGNOR-97639 |
| PHLPP1 | dephosphorylation down-regulates ⊣ | RAF1 PSer338 | dephosphorylation up-regulates → | RAF1 | 24530606 | SIGNOR-237449 |
| PP2CA_R1A_R2A | dephosphorylation down-regulates ⊣ | RAF1 PSer259 | dephosphorylation down-regulates ⊣ | RAF1 | 16239230 | SIGNOR-243534 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86137 |
| PPP1CA | dephosphorylation down-regulates ⊣ | RAF1 PSer259 | dephosphorylation down-regulates ⊣ | RAF1 | 16630891 | SIGNOR-251649 |
| PRKAA1 | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86133 |
| PRKCB | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37474 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 12801936 | SIGNOR-250041 |
| PKN1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 15849194 | SIGNOR-135679 |
| PRKCA | phosphorylation up-regulates → | RAF1 PSer499 | phosphorylation down-regulates ⊣ | RAF1 | 12551925 | SIGNOR-97644 |
| AMPK | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation up-regulates → | RAF1 | 9091312 | SIGNOR-216616 |
| MAPK3 | phosphorylation up-regulates → | RAF1 PSer301 | phosphorylation down-regulates ⊣ | RAF1 | 16407412 | SIGNOR-143696 |
| SRC | phosphorylation up-regulates → | RAF1 PTyr340 | phosphorylation up-regulates → | RAF1 | 10998357 | SIGNOR-82150 |
| AKT1 | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 10576741 | SIGNOR-252588 |
| JAK2 | phosphorylation up-regulates → | RAF1 PTyr341 | phosphorylation up-regulates → | RAF1 | 8876196 | SIGNOR-251362 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA1 | phosphorylation down-regulates | RAF1 | SIGNOR-47148 |
| MAPK1 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-249439 |
| MAPK3 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-143692 |
| MAPK1 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-249443 |
| MAP2K1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-279627 |
| PRKCG | phosphorylation → up-regulates | RAF1 | SIGNOR-37545 |
| Gbeta | phosphorylation down-regulates | RAF1 | SIGNOR-270010 |
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-72669 |
| PRKACA | phosphorylation → down-regulates activity | RAF1 | SIGNOR-250040 |
| AKT2 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-235678 |
| PDPK1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-280063 |
| MAPK3 | phosphorylation down-regulates | RAF1 | SIGNOR-64172 |
| PLK1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278190 |
| PRKCA | phosphorylation → up-regulates | RAF1 | SIGNOR-97648 |
| AKT1 | phosphorylation down-regulates | RAF1 | SIGNOR-147963 |
| ERK1/2 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-244677 |
| AMPK | phosphorylation down-regulates | RAF1 | SIGNOR-216523 |
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-244333 |
| CDC25A | dephosphorylation down-regulates | RAF1 | SIGNOR-32548 |
| PKN1 | phosphorylation → up-regulates | RAF1 | SIGNOR-112549 |
| PRKCA | phosphorylation down-regulates | RAF1 | SIGNOR-34761 |
| SRC | phosphorylation → up-regulates | RAF1 | SIGNOR-32081 |
| PRKACA | phosphorylation down-regulates | RAF1 | SIGNOR-86145 |
| MAPK3 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-143688 |
| MAPK1 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-249441 |
| PRKCG | phosphorylation → up-regulates | RAF1 | SIGNOR-37541 |
| MAPK1 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-249444 |
| ERK1/2 | phosphorylation down-regulates | RAF1 | SIGNOR-244688 |
| PRKACA | phosphorylation → down-regulates activity | RAF1 | SIGNOR-250039 |
| PAK3 | phosphorylation → up-regulates | RAF1 | SIGNOR-62043 |
| JAK2 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-251361 |
| RAF1 | phosphorylation → unknown | RAF1 | SIGNOR-248917 |
| PRKCB | phosphorylation → up-regulates | RAF1 | SIGNOR-37478 |
| PRKACA | phosphorylation down-regulates | RAF1 | SIGNOR-86141 |
| ERK1/2 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-244681 |
| MAPK1 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-249442 |
| PAK6 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278971 |
| KSR1 | phosphorylation → up-regulates | RAF1 | SIGNOR-85386 |
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-244337 |
| PAK1 | phosphorylation → up-regulates | RAF1 | SIGNOR-180812 |
| ERK1/2 | phosphorylation down-regulates | RAF1 | SIGNOR-244685 |
| RAF1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-235770 |
| SRC | phosphorylation → up-regulates | RAF1 | SIGNOR-97635 |
| PRKCA | phosphorylation → up-regulates | RAF1 | SIGNOR-37470 |
| PRKCA | phosphorylation → unknown | RAF1 | SIGNOR-37466 |
| MAPK1 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-249440 |
| PLK1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278191 |
| PRKCA | phosphorylation → unknown | RAF1 | SIGNOR-37844 |
| PP2Ca_R1A_Bd | dephosphorylation → up-regulates activity | RAF1 | SIGNOR-243538 |
| PAK1 | phosphorylation → up-regulates | RAF1 | SIGNOR-180808 |
| PPP5C | dephosphorylation → down-regulates activity | RAF1 | SIGNOR-248537 |
| SRC | phosphorylation → up-regulates | RAF1 | SIGNOR-97639 |
| PHLPP1 | dephosphorylation → down-regulates activity | RAF1 | SIGNOR-237449 |
| PP2CA_R1A_R2A | dephosphorylation → up-regulates activity | RAF1 | SIGNOR-243534 |
| PRKACA | phosphorylation → down-regulates activity | RAF1 | SIGNOR-86137 |
| MAPK3 | phosphorylation down-regulates | RAF1 | SIGNOR-133345 |
| PPP1CA | dephosphorylation → up-regulates activity | RAF1 | SIGNOR-251649 |
| PRKAA1 | phosphorylation down-regulates | RAF1 | SIGNOR-86133 |
| PRKCB | phosphorylation → up-regulates | RAF1 | SIGNOR-37474 |
| AKT1 | phosphorylation down-regulates | RAF1 | SIGNOR-252531 |
| PRKACA | phosphorylation → down-regulates activity | RAF1 | SIGNOR-250041 |
| PKN1 | phosphorylation → up-regulates | RAF1 | SIGNOR-135679 |
| PRKCA | phosphorylation → unknown | RAF1 | SIGNOR-97644 |
| AMPK | phosphorylation → up-regulates | RAF1 | SIGNOR-216616 |
| PPP2CA | dephosphorylation → up-regulates | RAF1 | SIGNOR-141170 |
| MAPK1 | phosphorylation down-regulates | RAF1 | SIGNOR-64169 |
| MAPK3 | phosphorylation down-regulates | RAF1 | SIGNOR-143696 |
| SRC | phosphorylation → up-regulates | RAF1 | SIGNOR-82150 |
| AKT1 | phosphorylation down-regulates | RAF1 | SIGNOR-252588 |
| JAK2 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-251362 |