Entity Details

Name ERK1/2_Ser289
ID P04049
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
MAPK1RAF1Ser289RSHSESAsPSALSSSphosphorylation
down-regulates activity		15664191SIGNOR-249440
ERK1/2RAF1Ser289RSHSESAsPSALSSSphosphorylation
down-regulates activity		15664191SIGNOR-244677
MAPK3RAF1Ser289RSHSESAsPSALSSSphosphorylation
down-regulates activity		15664191SIGNOR-143688
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
MAPK1phosphorylation
up-regulates
→
RAF1
PSer289		phosphorylation
down-regulates
⊣		RAF115664191SIGNOR-249440
ERK1/2phosphorylation
up-regulates
→
RAF1
PSer289		phosphorylation
down-regulates
⊣		RAF115664191SIGNOR-244677
MAPK3phosphorylation
up-regulates
→
RAF1
PSer289		phosphorylation
down-regulates
⊣		RAF115664191SIGNOR-143688
Regulator Mechanism/Effect Target SIGNOR-ID
MAPK1phosphorylation
→
down-regulates activity 		RAF1SIGNOR-249440
ERK1/2phosphorylation
→
down-regulates activity 		RAF1SIGNOR-244677
MAPK3phosphorylation
→
down-regulates activity 		RAF1SIGNOR-143688