| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates activity | 27003818 | SIGNOR-278191 |
| PAK1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates | 18775988 | SIGNOR-180812 |
| PKN1 | RAF1 | Ser339 | PRGQRDSsYYWEIEA | phosphorylation up-regulates | 15849194 | SIGNOR-135679 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 27003818 | SIGNOR-278191 |
| PAK1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 18775988 | SIGNOR-180812 |
| PKN1 | phosphorylation up-regulates → | RAF1 PSer339 | phosphorylation up-regulates → | RAF1 | 15849194 | SIGNOR-135679 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278191 |
| PAK1 | phosphorylation → up-regulates | RAF1 | SIGNOR-180812 |
| PKN1 | phosphorylation → up-regulates | RAF1 | SIGNOR-135679 |
