| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | dephosphorylation down-regulates activity | 24530606 | SIGNOR-237449 |
| PKN1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 11733498 | SIGNOR-112549 |
| PAK6 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 18465753 | SIGNOR-278971 |
| PAK1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 18775988 | SIGNOR-180808 |
| PLK1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 27003818 | SIGNOR-278190 |
| PAK3 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates | 9823899 | SIGNOR-62043 |
| PPP5C | RAF1 | Ser338 | RPRGQRDsSYYWEIE | dephosphorylation down-regulates activity | 16892053 | SIGNOR-248537 |
| MAP2K1 | RAF1 | Ser338 | RPRGQRDsSYYWEIE | phosphorylation up-regulates activity | 23360980 | SIGNOR-279627 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PHLPP1 | dephosphorylation down-regulates ⊣ | RAF1 PSer338 | dephosphorylation up-regulates → | RAF1 | 24530606 | SIGNOR-237449 |
| PKN1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 11733498 | SIGNOR-112549 |
| PAK6 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 18465753 | SIGNOR-278971 |
| PAK1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 18775988 | SIGNOR-180808 |
| PLK1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 27003818 | SIGNOR-278190 |
| PAK3 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 9823899 | SIGNOR-62043 |
| PPP5C | dephosphorylation down-regulates ⊣ | RAF1 PSer338 | dephosphorylation up-regulates → | RAF1 | 16892053 | SIGNOR-248537 |
| MAP2K1 | phosphorylation up-regulates → | RAF1 PSer338 | phosphorylation up-regulates → | RAF1 | 23360980 | SIGNOR-279627 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PHLPP1 | dephosphorylation → down-regulates activity | RAF1 | SIGNOR-237449 |
| PKN1 | phosphorylation → up-regulates | RAF1 | SIGNOR-112549 |
| PAK6 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278971 |
| PAK1 | phosphorylation → up-regulates | RAF1 | SIGNOR-180808 |
| PLK1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-278190 |
| PAK3 | phosphorylation → up-regulates | RAF1 | SIGNOR-62043 |
| PPP5C | dephosphorylation → down-regulates activity | RAF1 | SIGNOR-248537 |
| MAP2K1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-279627 |
