| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates | 7935389 | SIGNOR-34761 |
| PRKACA | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates | 11971957 | SIGNOR-86145 |
| PRKACA | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates activity | 12801936 | SIGNOR-250039 |
| MAPK1 | RAF1 | Ser43 | FGYQRRAsDDGKLTD | phosphorylation down-regulates activity | 15664191 | SIGNOR-249439 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 7935389 | SIGNOR-34761 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86145 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 12801936 | SIGNOR-250039 |
| MAPK1 | phosphorylation up-regulates → | RAF1 PSer43 | phosphorylation down-regulates ⊣ | RAF1 | 15664191 | SIGNOR-249439 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation down-regulates | RAF1 | SIGNOR-34761 |
| PRKACA | phosphorylation down-regulates | RAF1 | SIGNOR-86145 |
| PRKACA | phosphorylation → down-regulates activity | RAF1 | SIGNOR-250039 |
| MAPK1 | phosphorylation → down-regulates activity | RAF1 | SIGNOR-249439 |
