| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RAF1 | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation up-regulates activity | 19595761 | SIGNOR-235770 |
| PRKAA1 | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation down-regulates | 9091312 | SIGNOR-47148 |
| PRKACA | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation down-regulates activity | 11971957 | SIGNOR-86137 |
| AMPK | RAF1 | Ser621 | PKINRSAsEPSLHRA | phosphorylation up-regulates | 9091312 | SIGNOR-216616 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RAF1 | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation up-regulates → | RAF1 | 19595761 | SIGNOR-235770 |
| PRKAA1 | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation down-regulates ⊣ | RAF1 | 9091312 | SIGNOR-47148 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86137 |
| AMPK | phosphorylation up-regulates → | RAF1 PSer621 | phosphorylation up-regulates → | RAF1 | 9091312 | SIGNOR-216616 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RAF1 | phosphorylation → up-regulates activity | RAF1 | SIGNOR-235770 |
| PRKAA1 | phosphorylation down-regulates | RAF1 | SIGNOR-47148 |
| PRKACA | phosphorylation → down-regulates activity | RAF1 | SIGNOR-86137 |
| AMPK | phosphorylation → up-regulates | RAF1 | SIGNOR-216616 |
