| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 10576741 | SIGNOR-72669 |
| AMPK | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 11971957 | SIGNOR-216523 |
| PP2Ca_R1A_Bd | RAF1 | Ser259 | SQRQRSTsTPNVHMV | dephosphorylation up-regulates activity | 16239230 | SIGNOR-243538 |
| PP2CA_R1A_R2A | RAF1 | Ser259 | SQRQRSTsTPNVHMV | dephosphorylation up-regulates activity | 16239230 | SIGNOR-243534 |
| PRKACA | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates activity | 12801936 | SIGNOR-250041 |
| AKT1 | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 10576741 | SIGNOR-252588 |
| AKT | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 16854453 | SIGNOR-244337 |
| PRKAA1 | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 11971957 | SIGNOR-86133 |
| PPP1CA | RAF1 | Ser259 | SQRQRSTsTPNVHMV | dephosphorylation up-regulates activity | 16630891 | SIGNOR-251649 |
| PRKACA | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 11971957 | SIGNOR-86141 |
| AKT1 | RAF1 | Ser259 | SQRQRSTsTPNVHMV | phosphorylation down-regulates | 16854453 | SIGNOR-147963 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 10576741 | SIGNOR-72669 |
| AMPK | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-216523 |
| PP2Ca_R1A_Bd | dephosphorylation down-regulates ⊣ | RAF1 PSer259 | dephosphorylation down-regulates ⊣ | RAF1 | 16239230 | SIGNOR-243538 |
| PP2CA_R1A_R2A | dephosphorylation down-regulates ⊣ | RAF1 PSer259 | dephosphorylation down-regulates ⊣ | RAF1 | 16239230 | SIGNOR-243534 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 12801936 | SIGNOR-250041 |
| AKT1 | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 10576741 | SIGNOR-252588 |
| AKT | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 16854453 | SIGNOR-244337 |
| PRKAA1 | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86133 |
| PPP1CA | dephosphorylation down-regulates ⊣ | RAF1 PSer259 | dephosphorylation down-regulates ⊣ | RAF1 | 16630891 | SIGNOR-251649 |
| PRKACA | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 11971957 | SIGNOR-86141 |
| AKT1 | phosphorylation up-regulates → | RAF1 PSer259 | phosphorylation down-regulates ⊣ | RAF1 | 16854453 | SIGNOR-147963 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-72669 |
| AMPK | phosphorylation down-regulates | RAF1 | SIGNOR-216523 |
| PP2Ca_R1A_Bd | dephosphorylation → up-regulates activity | RAF1 | SIGNOR-243538 |
| PP2CA_R1A_R2A | dephosphorylation → up-regulates activity | RAF1 | SIGNOR-243534 |
| PRKACA | phosphorylation → down-regulates activity | RAF1 | SIGNOR-250041 |
| AKT1 | phosphorylation down-regulates | RAF1 | SIGNOR-252588 |
| AKT | phosphorylation down-regulates | RAF1 | SIGNOR-244337 |
| PRKAA1 | phosphorylation down-regulates | RAF1 | SIGNOR-86133 |
| PPP1CA | dephosphorylation → up-regulates activity | RAF1 | SIGNOR-251649 |
| PRKACA | phosphorylation down-regulates | RAF1 | SIGNOR-86141 |
| AKT1 | phosphorylation down-regulates | RAF1 | SIGNOR-147963 |
