| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation unknown | 12551925 | SIGNOR-37844 |
| PRKCG | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation up-regulates | 8288587 | SIGNOR-37541 |
| PRKCA | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation up-regulates | 8288587 | SIGNOR-37470 |
| PRKCB | RAF1 | Ser497 | ATVKSRWsGSQQVEQ | phosphorylation up-regulates | 8288587 | SIGNOR-37474 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCA | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation down-regulates ⊣ | RAF1 | 12551925 | SIGNOR-37844 |
| PRKCG | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37541 |
| PRKCA | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37470 |
| PRKCB | phosphorylation up-regulates → | RAF1 PSer497 | phosphorylation up-regulates → | RAF1 | 8288587 | SIGNOR-37474 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKCA | phosphorylation → unknown | RAF1 | SIGNOR-37844 |
| PRKCG | phosphorylation → up-regulates | RAF1 | SIGNOR-37541 |
| PRKCA | phosphorylation → up-regulates | RAF1 | SIGNOR-37470 |
| PRKCB | phosphorylation → up-regulates | RAF1 | SIGNOR-37474 |
