| Name | NR3C1 |
| ID | P04150 |
| Role | substrate |
| Enzymatic Domains |
NR LBD 524-758 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| Gbeta | NR3C1 | – | phosphorylation down-regulates | 9199329 | SIGNOR-270098 | |
| GSK3B | NR3C1 | Ser404 | SMRPDVSsPPSSSST | phosphorylation down-regulates activity | 18838540 | SIGNOR-181541 |
| SGK1 | NR3C1 | Ser203 | DLEFSSGsPGKETNE | phosphorylation up-regulates activity | 23650397 | SIGNOR-251669 |
| MAPK14 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates | 20660302 | SIGNOR-255952 |
| CDK2 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates activity | 9199329 | SIGNOR-249427 |
| AKT | NR3C1 | Ser134 | ANLNRSTsVPENPKS | phosphorylation down-regulates | 24291004 | SIGNOR-236216 |
| SGK1 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates activity | 23650397 | SIGNOR-251670 |
| MAPK3 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 9199329 | SIGNOR-154409 |
| CDK2 | NR3C1 | Ser203 | DLEFSSGsPGKETNE | phosphorylation up-regulates activity | 9199329 | SIGNOR-249426 |
| PPP1CA | NR3C1 | – | dephosphorylation up-regulates activity | 32585168 | SIGNOR-277161 | |
| CDK5 | NR3C1 | Ser203 | DLEFSSGsPGKETNE | phosphorylation down-regulates activity | 17440046 | SIGNOR-154401 |
| MAPK14 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates | 15817653 | SIGNOR-135198 |
| PPP5C | NR3C1 | Ser211 | PGKETNEsPWRSDLL | dephosphorylation down-regulates activity | 19586900 | SIGNOR-248538 |
| PRKDC | NR3C1 | Ser508 | QQATTGVsQETSENP | phosphorylation unknown | 9038175 | SIGNOR-248965 |
| ERK1/2 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 9199329 | SIGNOR-93554 |
| MAPK1 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates activity | 9199329 | SIGNOR-249428 |
| MAPK8 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 12351702 | SIGNOR-93558 |
| AKT1 | NR3C1 | Ser134 | ANLNRSTsVPENPKS | phosphorylation down-regulates | 24291004 | SIGNOR-252543 |
| CDK5 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation down-regulates activity | 17440046 | SIGNOR-154405 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | NR3C1 PSer404 | phosphorylation down-regulates ⊣ | NR3C1 | 18838540 | SIGNOR-181541 |
| SGK1 | phosphorylation up-regulates → | NR3C1 PSer203 | phosphorylation up-regulates → | NR3C1 | 23650397 | SIGNOR-251669 |
| MAPK14 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 20660302 | SIGNOR-255952 |
| CDK2 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 9199329 | SIGNOR-249427 |
| AKT | phosphorylation up-regulates → | NR3C1 PSer134 | phosphorylation down-regulates ⊣ | NR3C1 | 24291004 | SIGNOR-236216 |
| SGK1 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 23650397 | SIGNOR-251670 |
| MAPK3 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 9199329 | SIGNOR-154409 |
| CDK2 | phosphorylation up-regulates → | NR3C1 PSer203 | phosphorylation up-regulates → | NR3C1 | 9199329 | SIGNOR-249426 |
| CDK5 | phosphorylation up-regulates → | NR3C1 PSer203 | phosphorylation down-regulates ⊣ | NR3C1 | 17440046 | SIGNOR-154401 |
| MAPK14 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 15817653 | SIGNOR-135198 |
| PPP5C | dephosphorylation down-regulates ⊣ | NR3C1 PSer211 | dephosphorylation up-regulates → | NR3C1 | 19586900 | SIGNOR-248538 |
| PRKDC | phosphorylation up-regulates → | NR3C1 PSer508 | phosphorylation down-regulates ⊣ | NR3C1 | 9038175 | SIGNOR-248965 |
| ERK1/2 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 9199329 | SIGNOR-93554 |
| MAPK1 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 9199329 | SIGNOR-249428 |
| MAPK8 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 12351702 | SIGNOR-93558 |
| AKT1 | phosphorylation up-regulates → | NR3C1 PSer134 | phosphorylation down-regulates ⊣ | NR3C1 | 24291004 | SIGNOR-252543 |
| CDK5 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation down-regulates ⊣ | NR3C1 | 17440046 | SIGNOR-154405 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| Gbeta | phosphorylation down-regulates | NR3C1 | SIGNOR-270098 |
| GSK3B | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-181541 |
| SGK1 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-251669 |
| MAPK14 | phosphorylation → up-regulates | NR3C1 | SIGNOR-255952 |
| CDK2 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-249427 |
| AKT | phosphorylation down-regulates | NR3C1 | SIGNOR-236216 |
| SGK1 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-251670 |
| MAPK3 | phosphorylation down-regulates | NR3C1 | SIGNOR-154409 |
| CDK2 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-249426 |
| PPP1CA | dephosphorylation → up-regulates activity | NR3C1 | SIGNOR-277161 |
| CDK5 | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-154401 |
| MAPK14 | phosphorylation → up-regulates | NR3C1 | SIGNOR-135198 |
| PPP5C | dephosphorylation → down-regulates activity | NR3C1 | SIGNOR-248538 |
| PRKDC | phosphorylation → unknown | NR3C1 | SIGNOR-248965 |
| ERK1/2 | phosphorylation down-regulates | NR3C1 | SIGNOR-93554 |
| MAPK1 | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-249428 |
| MAPK8 | phosphorylation down-regulates | NR3C1 | SIGNOR-93558 |
| AKT1 | phosphorylation down-regulates | NR3C1 | SIGNOR-252543 |
| CDK5 | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-154405 |