Summary

Name NR3C1
Full Name Glucocorticoid receptor
Synonyms GR, Nuclear receptor subfamily 3 group C member 1 | GRL
Primary ID P04150
Links - -
Type protein
Relations 105
Pathways Adipogenesis, Glucocorticoid Receptor
Inhibitors mifepristone
Function Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NR3C1 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NR3C1 0.22
Publications: 2 Organism: In Vitro
Pathways:Adipogenesis
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation NR3C1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR3C1 0.2
Publications: 2 Organism: Mus Musculus, Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.23
Publications: 3 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.14
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ img/unknown.png phosphorylation NR3C1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.25
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA 0.28
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NR3C1 0.45
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.23
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.24
Publications: 4 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation PCK1 0.2
Publications: 2 Organism: Pongo Pygmaeus, Rattus Norvegicus
+ up-regulates activity img/direct-activation.png binding CEBPB 0.31
Publications: 2 Organism: Mus Musculus, Rattus Norvegicus
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png binding CAV1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HNF4A 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation JUN 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ up-regulates img/direct-activation.png binding LCK 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ATP1B1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.25
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.32
Publications: 3 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity img/direct-activation.png transcriptional regulation CEBPD 0.28
Publications: 2 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOXO3 0.14
Publications: 1 Organism: Mus Musculus
Tissue: Liver
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF15 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.23
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR2F2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A3 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png NR3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding HDAC1 0.14
Publications: 1 Organism: Rattus Norvegicus
Tissue: Liver
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PPARG 0.32
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKBIA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation SGK1 0.14
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TSC22D3 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding NR3C1 0.25
Publications: 1 Organism: In Vitro
+ down-regulates activity img/indirect_inhibition.png binding MAPK8 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/direct_inhibition.png chemical inhibition NR3C1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.23
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates activity img/indirect_inhibition.png binding MAPK14 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/indirect_inhibition.png MAPK1 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid Receptor
+ down-regulates activity img/indirect_inhibition.png MAPK3 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid Receptor
+ up-regulates quantity img/direct-activation.png DUSP1 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RXRA 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CEBPA 0.28
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.31
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UGT1A1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT5A 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png binding NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NFKB1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor
+ down-regulates img/direct_inhibition.png binding NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation AR 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NR3C1 0.14
Publications: 1 Organism: Pongo Pygmaeus
+ up-regulates activity img/direct-activation.png binding NR3C1 0.34
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.28
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLF5 0.14
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLF9 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Inflammation 0.36
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding NR3C1/STAT5A 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NR3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR3C1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.14
Publications: 1 Organism: In Vitro
+ up-regulates img/indirect-activation.png NR3C2 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation IRAK3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation G6PC 0.14
Publications: 1 Organism: Pongo Pygmaeus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NCOA1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid Receptor