| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 12351702 | SIGNOR-93558 |
| MAPK3 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 9199329 | SIGNOR-154409 |
| ERK1/2 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates | 9199329 | SIGNOR-93554 |
| MAPK1 | NR3C1 | Ser226 | IDENCLLsPLAGEDD | phosphorylation down-regulates activity | 9199329 | SIGNOR-249428 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK8 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 12351702 | SIGNOR-93558 |
| MAPK3 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 9199329 | SIGNOR-154409 |
| ERK1/2 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 9199329 | SIGNOR-93554 |
| MAPK1 | phosphorylation up-regulates → | NR3C1 PSer226 | phosphorylation down-regulates ⊣ | NR3C1 | 9199329 | SIGNOR-249428 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK8 | phosphorylation down-regulates | NR3C1 | SIGNOR-93558 |
| MAPK3 | phosphorylation down-regulates | NR3C1 | SIGNOR-154409 |
| ERK1/2 | phosphorylation down-regulates | NR3C1 | SIGNOR-93554 |
| MAPK1 | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-249428 |
