| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation down-regulates activity | 17440046 | SIGNOR-154405 |
| CDK2 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates activity | 9199329 | SIGNOR-249427 |
| MAPK14 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates | 20660302 | SIGNOR-255952 |
| SGK1 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates activity | 23650397 | SIGNOR-251670 |
| MAPK14 | NR3C1 | Ser211 | PGKETNEsPWRSDLL | phosphorylation up-regulates | 15817653 | SIGNOR-135198 |
| PPP5C | NR3C1 | Ser211 | PGKETNEsPWRSDLL | dephosphorylation down-regulates activity | 19586900 | SIGNOR-248538 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation down-regulates ⊣ | NR3C1 | 17440046 | SIGNOR-154405 |
| CDK2 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 9199329 | SIGNOR-249427 |
| MAPK14 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 20660302 | SIGNOR-255952 |
| SGK1 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 23650397 | SIGNOR-251670 |
| MAPK14 | phosphorylation up-regulates → | NR3C1 PSer211 | phosphorylation up-regulates → | NR3C1 | 15817653 | SIGNOR-135198 |
| PPP5C | dephosphorylation down-regulates ⊣ | NR3C1 PSer211 | dephosphorylation up-regulates → | NR3C1 | 19586900 | SIGNOR-248538 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5 | phosphorylation → down-regulates activity | NR3C1 | SIGNOR-154405 |
| CDK2 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-249427 |
| MAPK14 | phosphorylation → up-regulates | NR3C1 | SIGNOR-255952 |
| SGK1 | phosphorylation → up-regulates activity | NR3C1 | SIGNOR-251670 |
| MAPK14 | phosphorylation → up-regulates | NR3C1 | SIGNOR-135198 |
| PPP5C | dephosphorylation → down-regulates activity | NR3C1 | SIGNOR-248538 |
